trRosettaRNA: automated prediction of RNA 3D structure with transformer network

W Wang, C Feng, R Han, Z Wang, L Ye, Z Du… - Nature …, 2023 - nature.com
RNA 3D structure prediction is a long-standing challenge. Inspired by the recent
breakthrough in protein structure prediction, we developed trRosettaRNA, an automated …

Machine learning for RNA 2D structure prediction benchmarked on experimental data

M Justyna, M Antczak, M Szachniuk - Briefings in Bioinformatics, 2023 - academic.oup.com
Since the 1980s, dozens of computational methods have addressed the problem of
predicting RNA secondary structure. Among them are those that follow standard optimization …

Has AlphaFold 3 reached its success for RNAs?

C Bernard, G Postic, S Ghannay, F Tahi - bioRxiv, 2024 - biorxiv.org
Predicting the 3D structure of RNA is a significant challenge despite ongoing advancements
in the field. Although AlphaFold has successfully addressed this problem for proteins, RNA …

Comparative analysis of RNA 3D structure prediction methods: towards enhanced modeling of RNA–ligand interactions

C Nithin, S Kmiecik, R Błaszczyk… - Nucleic Acids …, 2024 - academic.oup.com
Accurate RNA structure models are crucial for designing small molecule ligands that
modulate their functions. This study assesses six standalone RNA 3D structure prediction …

RNA-TorsionBERT: leveraging language models for RNA 3D torsion angles prediction

C Bernard, G Postic, S Ghannay, F Tahi - Bioinformatics, 2025 - academic.oup.com
Motivation Predicting the 3D structure of RNA is an ongoing challenge that has yet to be
completely addressed despite continuous advancements. RNA 3D structures rely on …

[HTML][HTML] ModelCIF: An extension of PDBx/mmCIF data representation for computed structure models

B Vallat, G Tauriello, S Bienert, J Haas… - Journal of molecular …, 2023 - Elsevier
Abstract ModelCIF (github. com/ihmwg/ModelCIF) is a data information framework
developed for and by computational structural biologists to enable delivery of Findable …

Advancing RNA 3D structure prediction: Exploring hierarchical and hybrid approaches in CASP15

J Li, S Zhang, SJ Chen - Proteins: Structure, Function, and …, 2023 - Wiley Online Library
In CASP15, we used an integrated hierarchical and hybrid approach to predict RNA
structures. The approach involves three steps. First, with the use of physics‐based methods …

[HTML][HTML] Discovery of a trefoil knot in the RydC RNA: Challenging previous notions of RNA topology

W Niemyska, S Mukherjee, BA Gren… - Journal of Molecular …, 2024 - Elsevier
Knots are very common in polymers, including DNA and protein molecules. Yet, no genuine
knot has been identified in natural RNA molecules to date. Upon re-examining …

Computational modeling of DNA 3D structures: From dynamics and mechanics to folding

ZC Mu, YL Tan, J Liu, BG Zhang, YZ Shi - Molecules, 2023 - mdpi.com
DNA carries the genetic information required for the synthesis of RNA and proteins and
plays an important role in many processes of biological development. Understanding the …

[HTML][HTML] mRNA vaccine sequence and structure design and optimization: Advances and challenges

L **, Y Zhou, S Zhang, SJ Chen - Journal of Biological Chemistry, 2024 - Elsevier
Messenger RNA (mRNA) vaccines have emerged as a powerful tool against communicable
diseases and cancers, as demonstrated by their huge success during the coronavirus …