[HTML][HTML] The genetic causes of male factor infertility: a review
OBJECTIVE: To illustrate the necessity for an enhanced understanding of the genetic basis
of male factor infertility, to present a comprehensive synopsis of these genetic elements, and …
of male factor infertility, to present a comprehensive synopsis of these genetic elements, and …
Developmental model for the pathogenesis of testicular carcinoma in situ: genetic and environmental aspects
Carcinoma in situ testis (CIS), also known as intratubular germ cell neoplasia (ITGCN), is a
pre-invasive precursor of testicular germ cell tumours, the commonest cancer type of male …
pre-invasive precursor of testicular germ cell tumours, the commonest cancer type of male …
A multi-faceted approach to understanding male infertility: gene mutations, molecular defects and assisted reproductive techniques (ART)
Background The assisted reproductive techniques aimed to assist infertile couples have
their own offspring carry significant risks of passing on molecular defects to next …
their own offspring carry significant risks of passing on molecular defects to next …
The CAG repeat polymorphism within the androgen receptor gene and maleness1
M Zitzmann, E Nieschlag - International journal of andrology, 2003 - Wiley Online Library
The androgen testosterone and its metabolite dihydrotestosterone exert their effects on gene
expression and thus effect maleness via the androgen receptor (AR). A diverse range of …
expression and thus effect maleness via the androgen receptor (AR). A diverse range of …
Guidelines for the appropriate use of genetic tests in infertile couples
Research on genetic causes of male and female infertility rapidly expanded in the last years,
following the development of in vitro fertilising techniques. Genetic tests are now available to …
following the development of in vitro fertilising techniques. Genetic tests are now available to …
Phenotypic heterogeneity of mutations in androgen receptor gene
Androgen receptor (AR) gene has been extensively studied in diverse clinical conditions. In
addition to the point mutations, trinucleotide repeat (CAG and GGN) length polymorphisms …
addition to the point mutations, trinucleotide repeat (CAG and GGN) length polymorphisms …
Mutations at the mitochondrial DNA polymerase (POLG) locus associated with male infertility
AT Rovio, DR Marchington, S Donat, HC Schuppe… - Nature …, 2001 - nature.com
Human mitochondrial DNA polymerase, encoded by POLG, contains a polyglutamine tract
encoded by a CAG microsatellite repeat 1, 2. Analysis of POLG genotypes in different …
encoded by a CAG microsatellite repeat 1, 2. Analysis of POLG genotypes in different …
Challenges in testosterone measurement, data interpretation, and methodological appraisal of interventional trials
LW Trost, JP Mulhall - The journal of sexual medicine, 2016 - academic.oup.com
Introduction Male hypogonadism is a common condition, with an increasing body of
literature on diagnosis, implications, and management. Given the significant variability in …
literature on diagnosis, implications, and management. Given the significant variability in …
Male infertility and variation in CAG repeat length in the androgen receptor gene: a meta-analysis
Context: Many studies have investigated the association between male infertility and
trinucleotide repeat polymorphisms in the androgen receptor (AR) gene, but no …
trinucleotide repeat polymorphisms in the androgen receptor (AR) gene, but no …
Androgen receptor gene and male infertility
Androgens are critical steroid hormones that determine the expression of the male
phenotype. Their actions are mediated by a single androgen receptor (AR) which, upon …
phenotype. Their actions are mediated by a single androgen receptor (AR) which, upon …