Strategies to optimize the efficacy of anthelmintic drugs in ruminants
Anthelmintic resistance in human and animal pathogenic helminths has been spreading in
prevalence and severity. Multidrug resistance is a widespread problem in livestock animals …
prevalence and severity. Multidrug resistance is a widespread problem in livestock animals …
Understanding triclabendazole resistance
GP Brennan, I Fairweather, A Trudgett, E Hoey… - … and molecular pathology, 2007 - Elsevier
Triclabendazole (TCBZ) has been the drug of choice to treat liver fluke infections in livestock
for> 20 years, due to its high activity against both adult and juvenile flukes. More recently, it …
for> 20 years, due to its high activity against both adult and juvenile flukes. More recently, it …
Update on trematode infections in sheep
Trematode parasites live in the liver, fore stomachs or blood vessels of a wide range of
animals and humans. Most of them have a special economic and veterinary significance …
animals and humans. Most of them have a special economic and veterinary significance …
Drug transfer into target helminth parasites
The pharmacokinetics of an anthelmintic drug includes the time course of drug absorption,
distribution, metabolism and elimination from the host and determines the concentration of …
distribution, metabolism and elimination from the host and determines the concentration of …
Triclabendazole progress report, 2005–2009: an advancement of learning?
I Fairweather - Journal of helminthology, 2009 - cambridge.org
Triclabendazole (TCBZ) remains the drug of choice for treating infections of the liver fluke,
Fasciola hepatica in livestock and has become the main drug used to treat human cases of …
Fasciola hepatica in livestock and has become the main drug used to treat human cases of …
Functionalized benzimidazole scaffolds: privileged heterocycle for drug design in therapeutic medicine
Benzimidazole derivatives are crucial structural scaffolds found in diverse libraries of
biologically active compounds which are therapeutically useful agents in drug discovery and …
biologically active compounds which are therapeutically useful agents in drug discovery and …
Medicinal plants as a source of antiparasitics: an overview of experimental studies
Despite advances in modern human and veterinary medicine, gastrointestinal (GI) parasitic
infections remain a significant health issue worldwide, mainly in develo** countries …
infections remain a significant health issue worldwide, mainly in develo** countries …
Xenobiotic metabolizing enzymes and metabolism of anthelminthics in helminths
V Cvilink, J Lamka, L Skálová - Drug metabolism reviews, 2009 - Taylor & Francis
Anthelminthics remain the only accessible means in the struggle against helminth parasites,
which cause significant morbidity and mortality in man and farm animals. The treatment of …
which cause significant morbidity and mortality in man and farm animals. The treatment of …
Host pharmacokinetics and drug accumulation of anthelmintics within target helminth parasites of ruminants
Anthelmintic drugs require effective concentrations to be attained at the site of parasite
location for a certain period to assure their efficacy. The processes of absorption …
location for a certain period to assure their efficacy. The processes of absorption …
Human trichuriasis: whipworm genetics, phylogeny, transmission and future research directions
Human trichuriasis is a neglected tropical disease which affects hundreds of millions of
people worldwide and is particularly prevalent among children living in areas where …
people worldwide and is particularly prevalent among children living in areas where …