Ferroptosis, a type of regulated cell death driven by iron-dependent phospholipid
peroxidation, has captured much attention in the field of nanomedicine since it was coined in …

Superoxide dismutase (SOD) is a class of enzymes that restrict the biological oxidant cluster
enzyme system in the body, which can effectively respond to cellular oxidative stress, lipid …

Immunotherapy is currently the most promising treatment strategy for long-term tumor
regression. However, current cancer immunotherapy shows low response rates due to …

Ferroptosis therapy (FT) efficacy of tumors suffers from a relatively low concentration of
Fenton agents, limited hydrogen peroxide (H2O2) content, and insufficient acidity in the …

The antioxidant system, signed with reduced glutathione (GSH) overexpression, is the key
weapon for tumor to resist the attack by reactive oxygen species (ROS). Counteracting the …

Metabolism is the sum of the enzyme‐dependent chemical reactions, which produces
energy in catabolic process and synthesizes biomass in anabolic process, exhibiting high …

Most nanozymes in development for medical applications only exhibit single‐enzyme‐like
activity, and are thus limited by insufficient catalytic activity and dysfunctionality in complex …

The overexpression of polyamines in tumor cells contributes to the establishment of
immunosuppressive microenvironment and facilitates tumor growth. Here, it have …

A potential reason for the failure of tumor therapies is treatment resistance. Resistance to
chemotherapy, radiotherapy, and immunotherapy continues to be a major obstacle in clinic …

Single‐atom nanozymes (SAzymes) hold great promise in tumor therapy due to their
maximized atomic utilization and well‐defined electronic structures. However, they still face …