Advances in the biological sciences have led to an ongoing paradigm shift in toxicity testing
based on expanded application of high-throughput in vitro screening and in silico methods …

Tens-of-thousands of chemicals are registered in the US for use in countless processes and
products. Recent evidence suggests that many of these chemicals are measureable in …

Abstract The US Environmental Protection Agency (EPA) is faced with the challenge of
efficiently and credibly evaluating chemical safety often with limited or no available toxicity …

The use and production of chemical compounds are subjected to strong legislative pressure.
Chemical toxicity and adverse effects derived from exposure to chemicals are key regulatory …

Prioritizing the potential risk posed to human health by chemicals requires tools that can
estimate exposure from limited information. In this study, chemical structure and …

Accurate prediction of parameters related to the environmental exposure of chemicals is
crucial for the sound management of chemicals. However, the lack of large data sets for …

The chemical burden on the environment and human population is increasing.
Consequently, regulatory risk assessment must keep pace to manage, reduce, and prevent …

This consensus statement voices the agreement of scientific stakeholders from regulatory
agencies, academia and industry that a new framework needs adopting for assessment of …

Medicinal chemistry projects involve some steps aiming to develop a new drug, such as the
analysis of biological targets related to a given disease, the discovery and the development …

Chemical risk assessment relies on knowledge of hazard, the dose–response relationship,
and exposure to characterize potential risks to public health and the environment. A …