Neutrophil diversity in health and disease

C Silvestre-Roig, ZG Fridlender, M Glogauer… - Trends in …, 2019 - cell.com
New evidence has challenged the outdated dogma that neutrophils are a homogeneous
population of short-lived cells. Although neutrophil subpopulations with distinct functions …

Neutrophils at the crossroads of innate and adaptive immunity

C Rosales - Journal of Leucocyte Biology, 2020 - academic.oup.com
Neutrophils are the most abundant leukocytes in blood. From the circulation, they are quickly
mobilized to sites of inflammation and/or infection. At the affected tissues, neutrophils display …

The neutrophil life cycle

A Hidalgo, ER Chilvers, C Summers… - Trends in …, 2019 - cell.com
Neutrophils are recognized as an essential part of the innate immune response, but an
active debate still exists regarding the life cycle of these cells. Neutrophils first differentiate in …

Update on neutrophil function in severe inflammation

E Mortaz, SD Alipoor, IM Adcock, S Mumby… - Frontiers in …, 2018 - frontiersin.org
Neutrophils are main players in the effector phase of the host defense against micro-
organisms and have a major role in the innate immune response. Neutrophils show …

The inhibitory effect of curcumin on virus-induced cytokine storm and its potential use in the associated severe pneumonia

Z Liu, Y Ying - Frontiers in cell and developmental biology, 2020 - frontiersin.org
Coronavirus infection, including SARS-CoV, MERS-CoV, and SARS-CoV2, causes daunting
diseases that can be fatal because of lung failure and systemic cytokine storm. The …

Novel findings in neutrophil biology and their impact on cardiovascular disease

A Bonaventura, F Montecucco, F Dallegri… - Cardiovascular …, 2019 - academic.oup.com
Neutrophils are the most abundant circulating leucocytes in healthy humans. These cells are
central players during acute inflammatory responses, although a growing body of evidence …

On the origin of low-density neutrophils

M Hassani, P Hellebrekers, N Chen… - Journal of Leukocyte …, 2020 - academic.oup.com
Here we elaborate on the origin of low (er)-density neutrophils (LDNs) to better understand
the variation found in literature. Supplemented with original data, we test the hypothesis that …

The roles of NADPH oxidase in modulating neutrophil effector responses

MY Zeng, I Miralda, CL Armstrong… - Molecular oral …, 2019 - Wiley Online Library
Neutrophils are phagocytic innate immune cells essential for killing bacteria via activation of
a wide variety of effector responses and generation of large amounts of reactive oxygen …

Neutrophils in tuberculosis-associated inflammation and lung pathology

CN Muefong, JS Sutherland - Frontiers in immunology, 2020 - frontiersin.org
Protective immunity to Mycobacterium tuberculosis (Mtb)—the causative agent of
tuberculosis (TB)—is not fully understood but involves immune responses within the …

Neutrophil extracellular traps: signaling properties and disease relevance

T Li, Z Zhang, X Li, G Dong, M Zhang… - Mediators of …, 2020 - Wiley Online Library
Neutrophil extracellular traps (NETs) are characterized as extracellular DNA fibers
comprised of histone and cytoplasmic granule proteins. NETs were first described as a form …