The endoplasmic reticulum (ER) functions as a quality-control organelle for protein
homeostasis, or “proteostasis”. The protein quality control systems involve ER-associated …

Adult zebrafish generate new neurons in the brain and retina throughout life. Growth-related
neurogenesis allows a vigorous regenerative response to damage, and fish can regenerate …

Age‐related macular degeneration (AMD) is a leading cause of blindness. Vision loss is
caused by the retinal pigment epithelium (RPE) and photoreceptors atrophy and/or retinal …

Retinal dystrophies are a major cause of blindness for which there are currently no curative
treatments. Transplantation of stem cell‐derived neuronal progenitors to replace lost cells …

Astrocytes are the most abundant cell type in the central nervous system, have diverse
physiological roles in both health and disease, and exhibit phenotypic heterogeneity. In …

Highlights•This review reflects on the dual response of Müller cell after injury.•We review the
features that position Müller cells as a promising therapeutic target.•We discuss methods for …

Ocular surgeries and trauma predispose the eye to develop infectious endophthalmitis,
which often leads to vision loss. The mechanisms of initiation of innate defense in this …

Diabetes mellitus, especially type 2 diabetes mellitus (T2DM), has become a significant
public health burden. Rhizoma coptidis (RC), known as Huang Lian, is widely used for …

Despite their physiological roles, Müller glial cells are involved directly or indirectly in retinal
disease pathogenesis and are an interesting target for therapeutic approaches for retinal …

Diabetic retinopathy shares some similarity with chronic inflammation and Müller cells
dysfunction may play an important role in its initiation and progression since these cells are …