Cancer and the microbiota

WS Garrett - Science, 2015 - science.org
A host's microbiota may increase, diminish, or have no effect at all on cancer susceptibility.
Assigning causal roles in cancer to specific microbes and microbiotas, unraveling host …

A bacterial driver–passenger model for colorectal cancer: beyond the usual suspects

H Tjalsma, A Boleij, JR Marchesi… - Nature Reviews …, 2012 - nature.com
Cancer has long been considered a genetic disease. However, accumulating evidence
supports the involvement of infectious agents in the development of cancer, especially in …

A human colonic commensal promotes colon tumorigenesis via activation of T helper type 17 T cell responses

S Wu, KJ Rhee, E Albesiano, S Rabizadeh, X Wu… - Nature medicine, 2009 - nature.com
The intestinal flora may promote colon tumor formation. Here we explore immunologic
mechanisms of colonic carcinogenesis by a human colonic bacterium, enterotoxigenic …

[HTML][HTML] Microbiome and colorectal cancer: Roles in carcinogenesis and clinical potential

E Saus, S Iraola-Guzmán, JR Willis… - Molecular aspects of …, 2019 - Elsevier
The gastrointestinal tract harbors most of the microbiota associated with humans. In recent
years, there has been a surge of interest in assessing the relationships between the gut …

Microbiota dysbiosis and barrier dysfunction in inflammatory bowel disease and colorectal cancers: exploring a common ground hypothesis

LCH Yu - Journal of biomedical science, 2018 - Springer
Inflammatory bowel disease (IBD) is a multifactorial disease which arises as a result of the
interaction of genetic, environmental, barrier and microbial factors leading to chronic …

Microbial dysbiosis in colorectal cancer (CRC) patients

I Sobhani, J Tap, F Roudot-Thoraval, JP Roperch… - PloS one, 2011 - journals.plos.org
The composition of the human intestinal microbiota is linked to health status. The aim was to
analyze the microbiota of normal and colon cancer patients in order to establish cancer …

The microbiome in infectious disease and inflammation

K Honda, DR Littman - Annual review of immunology, 2012 - annualreviews.org
The mammalian alimentary tract harbors hundreds of species of commensal
microorganisms (microbiota) that intimately interact with the host and provide it with genetic …

[HTML][HTML] Next generation probiotics in disease amelioration

CJ Chang, TL Lin, YL Tsai, TR Wu, WF Lai… - Journal of food and drug …, 2019 - Elsevier
Studies on the role of gut commensal bacteria in health development have rapidly attracted
much more attention beyond the classical pathogens over the last decade. Many important …

The gut microbiome modulates colon tumorigenesis

JP Zackular, NT Baxter, KD Iverson, WD Sadler… - MBio, 2013 - Am Soc Microbiol
Recent studies have shown that individuals with colorectal cancer have an altered gut
microbiome compared to healthy controls. It remains unclear whether these differences are …

The human gut microbiome as a screening tool for colorectal cancer

JP Zackular, MAM Rogers, MT Ruffin IV… - Cancer prevention …, 2014 - AACR
Recent studies have suggested that the gut microbiome may be an important factor in the
development of colorectal cancer. Abnormalities in the gut microbiome have been reported …