Objective Use of the frailty index to measure an accumulation of deficits has been proven a
valuable method for identifying elderly people at risk for increased vulnerability, disease …

Fractalkine/CX3C chemokine ligand 1 (CX3CL1) is a chemokine involved in the anticancer
function of lymphocytes—mainly NK cells, T cells and dendritic cells. Its increased levels in …

Tumor‐associated macrophages (TAMs) are key components of the tumor
macroenvironment. Cancer‐and host cell‐derived signals generally drive the functions of …

Aims Our study aims to investigate the effect of micro RNA‐21 (miR‐21) on the proliferation,
senescence, and apoptosis of glioma cells by targeting SPRY 1 via the PTEN/PI 3K/AKT …

Lymphatic endothelial cells (LECs) release extracellular chemokines to guide the migration
of dendritic cells. In this study, we report that LECs also release basolateral exosome-rich …

Fractalkine/CX3CL1, the only member of the CX3C chemokine family, exists as a membrane‐
anchored molecule as well as in soluble form, each mediating different biological activities. It …

Inflammation is a component of glioma microenvironment. PTX3 is a component of the
humoral arm of innate immunity and a candidate marker of inflammation. In the present …

Glioblastoma, a highly malignant intracranial tumor, has acquired slow progress in
treatment. Previous clinical trials involving targeted therapy and immune checkpoint …

CX3CL1 or Fractalkine is a peculiar chemokine that can exist either in a soluble form, like all
the other chemokines, and as a cell membrane molecule. CX3CL1 is one of the most …

Metastasis-initiating cells (MICs) display stem cell-like features, cause metastatic
recurrences and defy chemotherapy, which leads to patients' demise. Here we show that …