The Genetic Epidemiology of Chronic Obstructive Pulmonary Disease (COPDGene) study,
which began in 2007, is an ongoing multicenter observational cohort study of more than …

We report here the first attempt to produce and use whole acellular (AC) lung as a matrix to
support development of engineered lung tissue from murine embryonic stem cells (mESCs) …

Lung function is inextricably linked to mechanics. On short timescales every breath
generates dynamic cycles of cell and matrix stretch, along with convection of fluids in the …

Rationale: The rate of decline of lung function is greater than age-related change in a
substantial proportion of patients with chronic obstructive pulmonary disease, even after …

While collagen is recognized as the predominant mechanical component of soft connective
tissues, the role of the non-fibrillar matrix (NFM) is less well understood. Even model …

Excessive tissue-level forces communicated to the microstructure and extracellular matrix of
soft tissues can lead to damage and failure through poorly understood physical processes …

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The non-linear stress-strain behavior of uniaxially-stretched lung parenchyma is thought to
be an emergent phenomenon arising from the ensemble behavior of its microscopic …

For an arterial replacement graft to be effective, it must possess the appropriate strength in
order to withstand long-term hemodynamic stress without failure, yet be compliant enough …

Extracellular matrix remodeling and tissue rupture contribute to the progression of
emphysema. Lung tissue elasticity is governed by the tensile stiffness of fibers and the …