[HTML][HTML] Mechanisms of long COVID and the path toward therapeutics

MJ Peluso, SG Deeks - Cell, 2024 - cell.com
Long COVID, a type of post-acute sequelae of severe acute respiratory syndrome
coronavirus 2 (SARS-CoV-2)(PASC) defined by medically unexplained symptoms following …

Damage to endothelial barriers and its contribution to long COVID

X Wu, M **ang, H **g, C Wang, VA Novakovic, J Shi - Angiogenesis, 2024 - Springer
The world continues to contend with COVID-19, fueled by the emergence of viral variants. At
the same time, a subset of convalescent individuals continues to experience persistent and …

Therapeutic trials for long COVID-19: A call to action from the interventions taskforce of the RECOVER initiative

H Bonilla, MJ Peluso, K Rodgers, JA Aberg… - Frontiers in …, 2023 - frontiersin.org
Although most individuals recover from acute SARS-CoV-2 infection, a significant number
continue to suffer from Post-Acute Sequelae of SARS-CoV-2 (PASC), including the …

Long COVID: a review and proposed visualization of the complexity of long COVID

R Perumal, L Shunmugam, K Naidoo… - Frontiers in …, 2023 - frontiersin.org
Post-Acute Sequelae of Severe Acute Respiratory Syndrome Coronavirus–2 (SARS-CoV-2)
infection, or Long COVID, is a prevailing second pandemic with nearly 100 million affected …

A central role for amyloid fibrin microclots in long COVID/PASC: origins and therapeutic implications

DB Kell, GJ Laubscher, E Pretorius - Biochemical Journal, 2022 - portlandpress.com
Post-acute sequelae of COVID (PASC), usually referred to as 'Long COVID'(a phenotype of
COVID-19), is a relatively frequent consequence of SARS-CoV-2 infection, in which …

Are fibrinaloid microclots a cause of autoimmunity in Long Covid and other post-infection diseases?

DB Kell, E Pretorius - Biochemical Journal, 2023 - portlandpress.com
It is now well established that the blood-clotting protein fibrinogen can polymerise into an
anomalous form of fibrin that is amyloid in character; the resultant clots and microclots entrap …

Uncertainties about the roles of anticoagulation and microclots in post-acute sequelae of SARS-CoV-2 infection

JM Connors, RAS Ariëns - Journal of Thrombosis and Haemostasis, 2023 - Elsevier
Three years after the start of the pandemic, approaches to the prevention and treatment of
acute Covid-19 have been established. However, post-acute sequelae of SARS-CoV-2 …

Data-independent LC-MS/MS analysis of ME/CFS plasma reveals a dysregulated coagulation system, endothelial dysfunction, downregulation of complement …

M Nunes, M Vlok, A Proal, DB Kell… - Cardiovascular …, 2024 - Springer
Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is a debilitating chronic
condition that is characterized by unresolved fatigue, post-exertion symptom exacerbation …