Over the last ten years, the development of synthetic polymers containing controlled
monomer sequences has become a prominent topic in fundamental and applied polymer …

Using scanning probe microscopy techniques, at low temperatures and in ultrahigh vacuum,
individual molecules adsorbed on surfaces can be probed with ultrahigh resolution to …

Proteins and lipids decorated with glycans are found throughout biological entities, playing
roles in biological functions and dysfunctions. Current analytical strategies for these glycan …

Native mass spectrometry (MS) has become widely accepted in structural biology, providing
information on stoichiometry, interactions, homogeneity, and shape of protein complexes …

Natural biopolymers have inspired the development of synthetic analogues that can adopt
defined conformations and assemble into 3D architectures. These compounds are mainly …

Using atomic manipulation, one can dissociate, form and rearrange bonds, as well as alter
the conformation or charge state of molecules. The molecular structures of reactants …

Imaging of biomolecules guides our understanding of their diverse structures and functions,.
Real-space imaging at sub-nanometre resolution using cryo-electron microscopy has …

Mass spectrometry (MS), a century-old analytical technique, is now emerging as a
preparative method. Electrospray deposition (ESD) of charged droplets generated by …

The formation and spreading of amyloid aggregates from the presynaptic protein α-
synuclein in the brain play central roles in the pathogenesis of Parkinson's disease. Here …

Past experimental results and molecular dynamics simulations provide evidence that, under
some conditions, electrospray ionization (ESI) of biomolecules produces ions that retain …