Polymeric delivery of therapeutic nucleic acids

R Kumar, CF Santa Chalarca, MR Bockman… - Chemical …, 2021‏ - ACS Publications
The advent of genome editing has transformed the therapeutic landscape for several
debilitating diseases, and the clinical outlook for gene therapeutics has never been more …

Static and dynamic: evolving biomaterial mechanical properties to control cellular mechanotransduction

W **e, X Wei, H Kang, H Jiang, Z Chu, Y Lin… - Advanced …, 2023‏ - Wiley Online Library
The extracellular matrix (ECM) is a highly dynamic system that constantly offers physical,
biological, and chemical signals to embraced cells. Increasing evidence suggests that …

Solvent-non-solvent rapid-injection for preparing nanostructured materials from micelles to hydrogels

C Lang, JA LaNasa, N Utomo, Y Xu, MJ Nelson… - Nature …, 2019‏ - nature.com
Due to their distinctive molecular architecture, ABA triblock copolymers will undergo specific
self-assembly processes into various nanostructures upon introduction into a B-block …

From precision polymers to complex materials and systems

JF Lutz, JM Lehn, EW Meijer… - Nature Reviews Materials, 2016‏ - nature.com
Complex chemical systems, such as living biological matter, are highly organized structures
based on discrete molecules in constant dynamic interactions. These natural materials can …

Fluoropolymer nanoparticles synthesized via reversible-deactivation radical polymerizations and their applications

Z Zhang, K Chen, B Ameduri, M Chen - Chemical Reviews, 2023‏ - ACS Publications
Fluorinated polymeric nanoparticles (FPNPs) combine unique properties of fluorocarbon
and polymeric nanoparticles, which has stimulated massive interest for decades. However …

Multiblock copolymer synthesis via RAFT emulsion polymerization

GKK Clothier, TR Guimarães, SW Thompson… - Chemical Society …, 2023‏ - pubs.rsc.org
A multiblock copolymer is a polymer of a specific structure that consists of multiple covalently
linked segments, each comprising a different monomer type. The control of the monomer …

Supramolecular polymers in aqueous media

E Krieg, MMC Bastings, P Besenius… - Chemical …, 2016‏ - ACS Publications
This review discusses one-dimensional supramolecular polymers that form in aqueous
media. First, naturally occurring supramolecular polymers are described, in particular …

Emerging applications for living crystallization-driven self-assembly

L MacFarlane, C Zhao, J Cai, H Qiu, I Manners - Chemical Science, 2021‏ - pubs.rsc.org
The use of crystallization as a tool to control the self-assembly of polymeric and molecular
amphiphiles in solution is attracting growing attention for the creation of non-spherical …

50th Anniversary Perspective: Functional Nanoparticles from the Solution Self-Assembly of Block Copolymers

U Tritschler, S Pearce, J Gwyther, GR Whittell… - …, 2017‏ - ACS Publications
This Perspective outlines recent advances concerning the formation and potential uses of
block copolymer micelles, a class of soft-matter-based nanoparticles of growing importance …

Polymersomes for therapeutic delivery of protein and nucleic acid macromolecules: from design to therapeutic applications

S Iqbal, M Blenner, A Alexander-Bryant… - …, 2020‏ - ACS Publications
Macromolecule-based therapeutic agents, particularly proteins, antigens, monoclonal
antibodies, transcription factors, nucleic acids, and gene editing enzymes, have the potential …