Colistin update on its mechanism of action and resistance, present and future challenges

FF Andrade, D Silva, A Rodrigues, C Pina-Vaz - Microorganisms, 2020 - mdpi.com
Colistin has been extensively used since the middle of the last century in animals,
particularly in swine, for the control of enteric infections. Colistin is presently considered the …

A review of antimicrobial resistance in poultry farming within low-resource settings

HD Hedman, KA Vasco, L Zhang - Animals, 2020 - mdpi.com
Simple Summary Poultry production can function as an instrument for poverty alleviation and
economic development. As low-income countries transition into higher incomes alongside …

Molecular mechanisms related to colistin resistance in Enterobacteriaceae

Z Aghapour, P Gholizadeh, K Ganbarov… - Infection and drug …, 2019 - Taylor & Francis
Colistin is an effective antibiotic for treatment of most multidrug-resistant Gram-negative
bacteria. It is used currently as a last-line drug for infections due to severe Gram-negative …

Molecular mechanisms of polymyxin resistance: knowns and unknowns

S Baron, L Hadjadj, JM Rolain, AO Olaitan - International journal of …, 2016 - Elsevier
Colistin, also referred to as polymyxin E, is an effective antibiotic against most multidrug-
resistant Gram-negative bacteria and is currently used as a last-line drug for treating severe …

Resistance to polymyxins in Gram-negative organisms

K Jeannot, A Bolard, P Plesiat - International journal of antimicrobial agents, 2017 - Elsevier
Polymyxins have recently been re-introduced into the therapeutic arsenal to combat
infections caused by multidrug-resistant Gram-negative bacteria. However, the emergence …

Colistin in pig production: chemistry, mechanism of antibacterial action, microbial resistance emergence, and one health perspectives

M Rhouma, F Beaudry, W Thériault… - Frontiers in …, 2016 - frontiersin.org
Colistin (Polymyxin E) is one of the few cationic antimicrobial peptides commercialized in
both human and veterinary medicine. For several years now, colistin has been considered …

Antibiotics and antibiotic resistance genes in animal manure–consequences of its application in agriculture

M Zalewska, A Błażejewska, A Czapko… - Frontiers in …, 2021 - frontiersin.org
Antibiotic resistance genes (ARGs) are a relatively new type of pollutant. The rise in
antibiotic resistance observed recently is closely correlated with the uncontrolled and …

The rise and spread of mcr plasmid-mediated polymyxin resistance

SC Nang, J Li, T Velkov - Critical reviews in microbiology, 2019 - Taylor & Francis
Polymyxins are important lipopeptide antibiotics that serve as the last-line defense against
multidrug-resistant (MDR) Gram-negative bacterial infections. Worryingly, the clinical utility …

Transferable resistance to colistin: a new but old threat

S Schwarz, AP Johnson - Journal of Antimicrobial …, 2016 - academic.oup.com
In this Leading article, we summarize current knowledge of the occurrence of the first and so
far only transferable colistin resistance gene, mcr-1. Its location on a conjugative plasmid is …

Production systems and important antimicrobial resistant-pathogenic bacteria in poultry: a review

PHW Mak, MA Rehman, EG Kiarie, E Topp… - Journal of Animal …, 2022 - Springer
Economic losses and market constraints caused by bacterial diseases such as colibacillosis
due to avian pathogenic Escherichia coli and necrotic enteritis due to Clostridium …