Homologous recombination (HR) is a major pathway for the repair of DNA double-strand
breaks in mammalian cells, the defining step of which is homologous strand exchange …

Defective DNA repair is a common hallmark of cancer. Homologous recombination is a DNA
repair pathway of clinical interest due to the sensitivity of homologous recombination …

Autism spectrum disorder (ASD) is a highly heritable and heterogeneous group of
neurodevelopmental phenotypes diagnosed in more than 1% of children. Common genetic …

Despite advances in biology and therapeutic modalities, existence of highly tumorigenic
glioma stem-like cells (GSCs) makes glioblastomas (GBMs) invincible. N6-methyl adenosine …

Deregulation of metabolism and disruption of genome integrity are hallmarks of cancer.
Increased levels of the metabolites 2-hydroxyglutarate, succinate and fumarate occur in …

The emergence of drug resistance limits the efficacy of targeted therapies in human tumors.
The prevalent view is that resistance is a fait accompli: when treatment is initiated, cancers …

Cells deficient in the Brca1 and Brca2 genes have reduced capacity to repair DNA double-
strand breaks by homologous recombination and consequently are hypersensitive to DNA …

The observation that BRCA1-and BRCA2-deficient cells are sensitive to inhibitors of poly
(ADP–ribose) polymerase (PARP) has spurred the development of cancer therapies that use …

2-Hydroxyglutarate (2HG) exists as two enantiomers,(R)-2HG and (S)-2HG, and both are
implicated in tumor progression via their inhibitory effects on α-ketoglutarate (αKG) …

G-quadruplex DNAs form four-stranded helical structures and are proposed to play key roles
in different cellular processes. Targeting G-quadruplex DNAs for cancer treatment is a very …