Diffraction (X-ray, neutron and electron) and electron cryo-microscopy are powerful methods
to determine three-dimensional macromolecular structures, which are required to …

Cryogenic electron microscopy (cryo-EM) enables structure determination of
macromolecular objects and their assemblies. Although the techniques have been …

This paper describes the current update on macromolecular model validation services that
are provided at the MolProbity website, emphasizing changes and additions since the …

Ramachandran plots report the distribution of the (ϕ, ψ) torsion angles of the protein
backbone and are one of the best quality metrics of experimental structure models. Typically …

Abstract Autophagy-related protein 18 (Atg18) participates in the elongation of early
autophagosomal structures in concert with Atg2 and Atg9 complexes. How Atg18 contributes …

An approach is demonstrated to obtain, in a sample-and time-efficient manner, multiple dose-
resolved crystal structures from room-temperature protein microcrystals using identical fixed …

The MolProbity web service provides macromolecular model validation to help correct local
errors, for the structural biology community worldwide. Here we highlight new validation …

The recycling of SNARE proteins following complex formation and membrane fusion is an
essential process in eukaryotic trafficking. A highly conserved AAA+ protein, NSF (N …

Highlights•Approaches to the structure determination and modelling of macromolecular
assemblies depend on the resolution of their cryo-EM map.•Insights into structure dynamics …

The power of computer simulations, including machine‐learning, has become an
inseparable part of scientific analysis of biological data. This has significantly impacted the …