Current status of vaccines for schistosomiasis

DP McManus, A Loukas - Clinical microbiology reviews, 2008 - journals.asm.org
Schistosomiasis, caused by trematode blood flukes of the genus Schistosoma, is recognized
as the most important human helminth infection in terms of morbidity and mortality. Infection …

Lactococcus lactis as a cell factory for delivery of therapeutic proteins

M Bahey-El-Din, CGM Gahan, BT Griffin - Current gene therapy, 2010 - benthamdirect.com
The food-grade bacterium Lactococcus lactis has been extensively investigated during the
last two decades as a delivery vector for therapeutic proteins, DNA and vaccine antigens …

Schistosoma mansoni Tegument Protein Sm29 Is Able to Induce a Th1-Type of Immune Response and Protection against Parasite Infection

FC Cardoso, GC Macedo, E Gava… - PLoS neglected …, 2008 - journals.plos.org
Background Schistosomiasis continues to be a significant public health problem. This
disease affects 200 million people worldwide and almost 800 million people are at risk of …

Oral delivery of DNA vaccine encoding VP28 against white spot syndrome virus in crayfish by attenuated Salmonella typhimurium

JF Ning, W Zhu, JP Xu, CY Zheng, XL Meng - Vaccine, 2009 - Elsevier
Protective immune responses in shrimp induced by DNA vaccines against white spot
syndrome virus (WSSV) with intramuscular injection have been reported in recent reports. In …

Current applications of oogram methodology in experimental schistosomiasis; fecundity of female Schistosoma mansoni and egg release in the intestine of AKR/J …

VLT Mati, AL Melo - Journal of helminthology, 2013 - cambridge.org
Oogram methodology permitted a direct assessment of the fecundity of Schistosoma
mansoni and the passage of parasite eggs from mesenteric vessels into the intestinal lumen …

Recent advances and methodological considerations on vaccine candidates for human schistosomiasis

U Panzner, JL Excler, JH Kim, F Marks… - Frontiers in tropical …, 2021 - frontiersin.org
Schistosomiasis remains a neglected tropical disease of major public health concern with
high levels of morbidity in various parts of the world. Although considerable efforts in …

Factors associated with resistance to Schistosoma mansoni infection in an endemic area of Bahia, Brazil

RR Oliveira, JP Figueiredo, LS Cardoso… - … American journal of …, 2012 - pmc.ncbi.nlm.nih.gov
Detailed knowledge of factors associated with resistance to Schistosoma mansoni infection
in endemic areas might facilitate more effective schistosomiasis control. We conducted a …

Kinetics of Lactococcus lactis growth and metabolite formation under aerobic and anaerobic conditions in the presence or absence of hemin

CQ Lan, G Oddone, DA Mills… - Biotechnology and …, 2006 - Wiley Online Library
The study of batch kinetics of Lactococcus lactis cell growth and product formation reveals
three distinct metabolic behaviors depending upon the availability of oxygen to the culture …

Peptides containing T cell epitopes, derived from Sm14, but not from paramyosin, induce a Th1 type of immune response, reduction in liver pathology and partial …

TCM Garcia, CT Fonseca, LGG Pacifico… - Acta tropica, 2008 - Elsevier
Sm14 and paramyosin are two major Schistosoma mansoni vaccine candidate antigens.
Recently, we have identified Sm14 and paramyosin epitopes that are recognized by T cells …

Sm 10.3, a member of the micro-exon gene 4 (MEG-4) family, induces erythrocyte agglutination in vitro and partially protects vaccinated mice against Schistosoma …

VP Martins, SB Morais, CS Pinheiro… - PLoS Neglected …, 2014 - journals.plos.org
Background The parasitic flatworm Schistosoma mansoni is a blood fluke that causes
schistosomiasis. Current schistosomiasis control strategies are mainly based on …