Discovery of CRBN as a target of thalidomide: a breakthrough for progress in the development of protein degraders
J Yamamoto, T Ito, Y Yamaguchi… - Chemical Society Reviews, 2022 - pubs.rsc.org
Progress in strategies aimed at breaking down therapeutic target proteins has led to a
paradigm shift in drug discovery. Thalidomide and its derivatives are the only protein …
paradigm shift in drug discovery. Thalidomide and its derivatives are the only protein …
Magnetic separations in biotechnology
Magnetic separations are probably one of the most versatile separation processes in
biotechnology as they are able to purify cells, viruses, proteins and nucleic acids directly …
biotechnology as they are able to purify cells, viruses, proteins and nucleic acids directly …
Synthesis and surface engineering of magnetic nanoparticles for environmental cleanup and pesticide residue analysis: a review
In recent years, water pollution and pesticide accumulation in the food chain have become a
serious environmental and health hazard problem. Direct determination of these …
serious environmental and health hazard problem. Direct determination of these …
Molecular mechanisms of thalidomide and its derivatives
T Ito, H Handa - Proceedings of the Japan Academy, Series B, 2020 - jstage.jst.go.jp
Thalidomide, originally developed as a sedative drug, causes multiple defects due to severe
teratogenicity, but it has been re-purposed for treating multiple myeloma, and derivatives …
teratogenicity, but it has been re-purposed for treating multiple myeloma, and derivatives …
Teratogenic effects of thalidomide: molecular mechanisms
T Ito, H Ando, H Handa - Cellular and Molecular Life Sciences, 2011 - Springer
Fifty years ago, prescription of the sedative thalidomide caused a worldwide epidemic of
multiple birth defects. The drug is now used in the treatment of leprosy and multiple …
multiple birth defects. The drug is now used in the treatment of leprosy and multiple …
Core–shell structural iron oxide hybrid nanoparticles: from controlled synthesis to biomedical applications
L Zhou, J Yuan, Y Wei - Journal of materials chemistry, 2011 - pubs.rsc.org
Superparamagnetic iron oxide nanoparticles have received great research attention due to
their wide spectrum of potential applications. Core–shell structures with iron oxide …
their wide spectrum of potential applications. Core–shell structures with iron oxide …
[PDF][PDF] Phase Transition of Electrooxidized to γ and Nanoparticles Using Sintering Treatment
In this work, electrosynthesis of Fe_3O_4 nanoparticles was carried out potentiostatically in
an aqueous solution of C_4H_12NCl which acts as supporting electrolyte and electrostatic …
an aqueous solution of C_4H_12NCl which acts as supporting electrolyte and electrostatic …
Molecular mechanisms of the teratogenic effects of thalidomide
T Asatsuma-Okumura, T Ito, H Handa - Pharmaceuticals, 2020 - mdpi.com
Thalidomide was sold worldwide as a sedative over 60 years ago, but it was quickly
withdrawn from the market due to its teratogenic effects. Thalidomide was later found to have …
withdrawn from the market due to its teratogenic effects. Thalidomide was later found to have …
Molecular mechanisms of cereblon-based drugs
T Asatsuma-Okumura, T Ito, H Handa - Pharmacology & therapeutics, 2019 - Elsevier
Thalidomide, well known for its potent teratogenicity, has been re-evaluated as a clinically
effective drug for the treatment of multiple myeloma. Although the direct target of thalidomide …
effective drug for the treatment of multiple myeloma. Although the direct target of thalidomide …
Thalidomide–a notorious sedative to a wonder anticancer drug
In the past 50 years, thalidomide has undergone a remarkable metamorphosis from a
notorious drug inducing birth defects into a highly effective therapy for treating leprosy and …
notorious drug inducing birth defects into a highly effective therapy for treating leprosy and …