Inflammatory responses play decisive roles at different stages of tumor development,
including initiation, promotion, malignant conversion, invasion, and metastasis. Inflammation …

CD8+ T cells specific for cancer cells are detected within tumours. However, despite their
presence, tumours progress. The clinical success of immune checkpoint blockade and …

Investigations into the interaction between radiotherapy and the host immune system have
uncovered new mechanisms that can potentially be exploited to improve the efficacy of …

Malignant transformation of cells depends on accumulation of DNA damage. Over the past
years we have learned that the T cell–based immune system frequently responds to the …

The abscopal effect is a phenomenon in which local radiotherapy is associated with the
regression of metastatic cancer at a distance from the irradiated site. The abscopal effect …

Despite lack of tumor control in many models, spontaneous T cell priming occurs frequently
in response to a growing tumor. However, the innate immune mechanisms that promote …

The recent success of cancer immunotherapy has demonstrated the power of the immune
system to clear tumors, generating renewed enthusiasm for identifying ways to induce …

Radiotherapy has been used for more than a hundred years as a local tumor treatment. The
occurrence of systemic antitumor effects manifesting as regression of tumors outside of the …

Patients with locally advanced cancer or distant metastasis frequently receive prolonged
treatment with chemotherapy and/or fractionated radiotherapy (RT). Despite the initial …

Genetic instability of tumor cells often leads to the occurrence of a large number of
mutations, and expression of non-synonymous mutations can produce tumor-specific …