The pulmonary circulation is a low-resistance, low-pressure, and high-compliance system
that allows the lungs to receive the entire cardiac output. Pulmonary arterial pressure is a …

Erectile dysfunction (ED) is a prevalent condition affecting men's sexual health, with
oxidative stress (OS) having recently been identified as a significant contributing causative …

Piezo is a mechanosensitive cation channel responsible for stretch-mediated Ca2+ and Na+
influx in multiple types of cells. Little is known about the functional role of Piezo1 in the lung …

The large K+ channel functional diversity in the pulmonary vasculature results from the
multitude of genes expressed encoding K+ channels, alternative RNA splicing, the post …

Concentric pulmonary vascular wall thickening due partially to increased pulmonary artery
(PA) smooth muscle cell (PASMC) proliferation contributes to elevating pulmonary vascular …

To execute the intricate process of development, cells coordinate across tissues and organs
to determine where each cell divides and differentiates. This coordination requires complex …

Background and Purpose Halofuginone is a febrifugine derivative originally isolated from
Chinese traditional herb Chang Shan that exhibits anti‐hypertrophic, anti‐fibrotic and anti …

Reduced expression and/or activity of Kv1. 5 channels (encoded by KCNA5) is a common
hallmark in human or experimental pulmonary arterial hypertension (PAH). Likewise …

Hypoxic Pulmonary Vasoconstriction (HPV) is an important physiological mechanism of the
lungs that matches perfusion to ventilation thus maximizing O2 saturation of the venous …

Osteogenesis Imperfecta (OI) is a heritable collagen-related bone dysplasia characterized
by bone fractures, growth deficiency and skeletal deformity. Type XIV OI is a recessive OI …