Immunity to malaria has been linked to the availability and function of helper CD4+ T cells,
cytotoxic CD8+ T cells and γδ T cells that can respond to both the asymptomatic liver stage …

Malaria caused by the Plasmodium family of parasites, especially P. falciparum and P. vivax,
is a major health problem in many countries in the tropical and subtropical regions of the …

Advancing our understanding of mechanisms of immune regulation in allergy, asthma,
autoimmune diseases, tumor development, organ transplantation, and chronic infections …

Abstract An attenuated Plasmodium falciparum (Pf) sporozoite (SPZ) vaccine, PfSPZ
Vaccine, is highly protective against controlled human malaria infection (CHMI) 3 weeks …

Greater than 80% of malaria-related mortality occurs in sub-Saharan Africa due to infections
with Plasmodium falciparum. The majority of P. falciparum-related mortality occurs in …

Interferon gamma (IFN-γ) is a key mediator of inflammatory immune responses induced
primarily by interleukin-12 (IL-12). IFN-γ secretion by both innate and adaptive immune cells …

Background Despite clinical descriptions of severe vivax malaria cases having been
reported, data regarding immunological and inflammatory patterns are scarce. In this report …

Natural killer (NK) cells are potent immune effectors that can be activated via antibody-
mediated Fc receptor engagement. Using multiparameter flow cytometry, we found that NK …

This review focuses on current clinical and immunological aspects of cerebral malaria
induced by Plasmodium falciparum infection. Albeit many issues concerning the …

Cellular responses to Plasmodium falciparum parasites, in particular interferon-gamma
(IFNγ) production, play an important role in anti-malarial immunity. However, clinical …