Abstract ERBB4 (HER4) is a member of the ERBB family of receptor tyrosine kinases, a
family that includes the epidermal growth factor receptor (EGFR/ERBB1/HER1), ERBB2 …

The Scribble cell polarity module, comprising Scribbled (Scrib), Discs-large (Dlg) and Lethal-
2-giant larvae (Lgl), has a tumor suppressive role in mammalian epithelial cancers. The …

Desmosomes have long been regarded as essential'spot welds' that externally glue together
cells within a tissue, and internally anchor the cytoskeletal network of intermediate filaments …

Abstract α-Amino-3-hydroxy-5-methyl-4-isoxazolepropionate receptors (AMPARs) are of
fundamental importance in the brain. They are responsible for the majority of fast excitatory …

Publisher Summary This chapter focuses on the ErbB-4 receptor, which is cloned from a
human mammary carcinoma cell line and shows to be related in sequence to other ErbB …

Recent data have renewed interest in the possible nuclear localization of receptor tyrosine
kinases, as well as their ligands. In one case, that of ErbB-4, the receptor is processed by …

Perturbations in neuregulin-1 (NRG1)/ErbB4 function have been associated with
schizophrenia. Affected patients exhibit altered levels of these proteins and display …

Neuronal morphogenesis, synaptogenesis and synaptic plasticity are fundamental aspects
of nervous system development. Much of our current understanding of how each of these …

The neuregulins were originally discovered in searches for the acetylcholine receptor-
inducing activity (ARIA), glial growth factor (GGF), and a ligand for the oncogene neu …

Neuregulin (NRG) regulates synapse formation and synaptic plasticity, but little is known
about the regulation of NRG signaling at synapses. Here we show that the NRG receptor …