Chronic pain in people with HIV: a common comorbidity and threat to quality of life
Evidence indicates that over half of all people with HIV (PWH) will experience nonmalignant
chronic pain throughout their lifetimes, with increasing prevalence as they age. Peripheral …
chronic pain throughout their lifetimes, with increasing prevalence as they age. Peripheral …
Pathogenic mechanisms of human immunodeficiency virus (HIV)-associated pain
Chronic pain is a prevalent neurological complication among individuals living with human
immunodeficiency virus (PLHIV) in the post-combination antiretroviral therapy (cART) era …
immunodeficiency virus (PLHIV) in the post-combination antiretroviral therapy (cART) era …
Purinergic signaling in infectious diseases of the central nervous system
VS Alves, R Leite-Aguiar, JP da Silva… - Brain, Behavior, and …, 2020 - Elsevier
The incidence of infectious diseases affecting the central nervous system (CNS) has been
increasing over the last several years. Among the reasons for the expansion of these …
increasing over the last several years. Among the reasons for the expansion of these …
Neuroinflammation in HIV-related neuropathic pain
HJ Lu, YY Fu, QQ Wei, ZJ Zhang - Frontiers in Pharmacology, 2021 - frontiersin.org
In the management of human immunodeficiency virus (HIV) infection around the world,
chronic complications are becoming a new problem along with the prolonged life …
chronic complications are becoming a new problem along with the prolonged life …
Reactive astrocytes in pain neural circuit pathogenesis
SJ Tang - Current opinion in neurobiology, 2022 - Elsevier
Reactive astrocytes are commonly activated in the spinal dorsal horn (SDH) of various
animal models of pathological pain. Previous investigations suggest an association between …
animal models of pathological pain. Previous investigations suggest an association between …
[HTML][HTML] A novel mu-delta opioid agonist demonstrates enhanced efficacy with reduced tolerance and dependence in mouse neuropathic pain models
Numerous studies have demonstrated a physiological interaction between the mu opioid
receptor (MOR) and delta opioid receptor (DOR) systems. A few studies have shown that …
receptor (MOR) and delta opioid receptor (DOR) systems. A few studies have shown that …
Microglia mediate HIV-1 gp120-induced synaptic degeneration in spinal pain neural circuits
HIV-1 infection of the nervous system causes various neurological diseases, and synaptic
degeneration is likely a critical step in the neuropathogenesis. Our prior studies revealed a …
degeneration is likely a critical step in the neuropathogenesis. Our prior studies revealed a …
Betulinic acid, derived from the desert lavender Hyptis emoryi, attenuates paclitaxel-, HIV-, and nerve injury–associated peripheral sensory neuropathy via block of N …
Abstract The Federal Pain Research Strategy recommended development of nonopioid
analgesics as a top priority in its strategic plan to address the significant public health crisis …
analgesics as a top priority in its strategic plan to address the significant public health crisis …
A neuron-to-astrocyte Wnt5a signal governs astrogliosis during HIV-associated pain pathogenesis
Chronic pain is the most common neurological disorder of HIV patients. Multiple
neuropathologies were identified in the pain pathway. Among them is the prominent …
neuropathologies were identified in the pain pathway. Among them is the prominent …
[HTML][HTML] Single-cell RNA-seq analysis reveals compartment-specific heterogeneity and plasticity of microglia
Microglia are ubiquitous central nervous system (CNS)-resident macrophages that maintain
homeostasis of neural tissues and protect them from pathogen attacks. Yet, their …
homeostasis of neural tissues and protect them from pathogen attacks. Yet, their …