Replication stress (RS) is a characteristic state of cancer cells as they tend to exchange
precision of replication for fast proliferation and increased genomic instability. To overcome …

Biomolecular condensates are cellular structures composed of membraneless assemblies
comprising proteins or nucleic acids. The formation of these condensates requires …

In colorectal cancer, oncogenic mutations transform a hierarchically organized and
homeostatic epithelium into invasive cancer tissue lacking visible organization. We sought to …

Cancer markers are measurable molecules in the blood or tissue that are produced by tumor
cells or immune cells in response to cancer progression. They play an important role in …

Nuclear paraspeckles are subnuclear bodies contracted by nuclear-enriched abundant
transcript 1 (NEAT1) long non-coding RNA, localised in the interchromatin space of …

Simple Summary Altered nuclear receptor signaling is well-established to contribute to a
range of hormone-dependent cancers and therefore they are therapeutic targets, for …

Background Exosomes, as extracellular membrane vesicles, play important roles in
intercellular communication and can influence tumour progression. Circular RNAs …

Splicing factor proline-and glutamine-rich (SFPQ) regulates transcripts in skeletal muscle
metabolism and tumorigenesis. As osteosarcoma (OS) is the most common malignant bone …

Colorectal cancer is the fourth cause of death from cancer worldwide, mainly due to the high
incidence of drug-resistance toward classic chemotherapeutic and newly targeted drugs. In …

Mesenchymal stem cells (MSCs) contribute to tumor pathogenesis and elicit antitumor
immune responses in tumor microenvironments. Nuclear proteins might be the main players …