Oxidative stress in the pathophysiology of type 2 diabetes and related complications: Current therapeutics strategies and future perspectives

JS Bhatti, A Sehrawat, J Mishra, IS Sidhu… - Free Radical Biology …, 2022 - Elsevier
Abstract Type 2 diabetes (T2DM) is a persistent metabolic disorder rising rapidly worldwide.
It is characterized by pancreatic insulin resistance and β-cell dysfunction. Hyperglycemia …

ROS and diseases: Role in metabolism and energy supply

S Yang, G Lian - Molecular and cellular biochemistry, 2020 - Springer
Researches dedicated to reactive oxygen species (ROS) had been performed for decades,
yet the outcomes remain controversial. With the relentless effort of studies, researchers have …

Obesogens: a unifying theory for the global rise in obesity

JJ Heindel, RH Lustig, S Howard… - International Journal of …, 2024 - nature.com
Despite varied treatment, mitigation, and prevention efforts, the global prevalence and
severity of obesity continue to worsen. Here we propose a combined model of obesity, a …

Oxidative stress-mediated beta cell death and dysfunction as a target for diabetes management

S Dinić, J Arambašić Jovanović, A Uskoković… - Frontiers in …, 2022 - frontiersin.org
The biggest drawback of a current diabetes therapy is the treatment of the consequences not
the cause of the disease. Regardless of the diabetes type, preservation and recovery of …

Mechanisms of activation of the transcription factor Nrf2 by redox stressors, nutrient cues, and energy status and the pathways through which it attenuates …

LE Tebay, H Robertson, ST Durant, SR Vitale… - Free Radical Biology …, 2015 - Elsevier
Abstract Nuclear factor-erythroid 2 p45-related factor 2 (Nrf2) regulates the basal and stress-
inducible expression of a battery of genes encoding key components of the glutathione …

Redox regulation of NLRP3 inflammasomes: ROS as trigger or effector?

JM Abais, M **a, Y Zhang, KM Boini… - Antioxidants & redox …, 2015 - liebertpub.com
Significance: Inflammasomes are multiprotein complexes localized within the cytoplasm of
the cell that are responsible for the maturation of proinflammatory cytokines such as …

[HTML][HTML] Mechanisms of action of metformin in type 2 diabetes: Effects on mitochondria and leukocyte-endothelium interactions

N Apostolova, F Iannantuoni, A Gruevska, J Muntane… - Redox biology, 2020 - Elsevier
Abstract Type 2 diabetes (T2D) is a very prevalent, multisystemic, chronic metabolic disorder
closely related to atherosclerosis and cardiovascular diseases. It is characterised by …

Oxidative stress, cardiolipin and mitochondrial dysfunction in nonalcoholic fatty liver disease

G Paradies, V Paradies, FM Ruggiero… - World journal of …, 2014 - pmc.ncbi.nlm.nih.gov
Nonalcoholic fatty liver disease (NAFLD) is today considered the most common form of
chronic liver disease, affecting a high proportion of the population worldwide. NAFLD …

Hyperbaric oxygen treatment: effects on mitochondrial function and oxidative stress

N Schottlender, I Gottfried, U Ashery - Biomolecules, 2021 - mdpi.com
Hyperbaric oxygen treatment (HBOT)—the administration of 100% oxygen at atmospheric
pressure (ATA) greater than 1 ATA—increases the proportion of dissolved oxygen in the …

Flavonoids and type 2 diabetes: Evidence of efficacy in clinical and animal studies and delivery strategies to enhance their therapeutic efficacy

T Hussain, B Tan, G Murtaza, G Liu, N Rahu… - Pharmacological …, 2020 - Elsevier
Diabetes mellitus type 2 (T2DM) is a metabolic disorder develops due to the overproduction
of free radicals where oxidative stress could contribute it. Possible factors are defective …