In an effort to develop novel strategies for delivery of drug candidates arising from rational
drug design and recombinant DNA technology, pharmaceutical scientists have begun to …

Many of the ichthyoses are associated with inherited disorders of lipid metabolism. These
disorders have provided unique models to dissect physiologic processes in normal …

• Dermatologists universally recognize that the unaffected skin of patients with atopic
dermatitis tends to be dry and slightly scaly. To characterize the functional properties of the …

X-linked ichthyosis is a relatively common syndromic form of ichthyosis most often due to
deletions in the gene encoding the microsomal enzyme, steroid sulfatase, located on the …

Cultured keratinocytes are frequently employed for studies of epidermal lipid metabolism.
Interpretation of experimental data may be complicated by donor to donor variability, the …

The enzyme serine palmitoyltransferase (SPT; EC 2.3. 1.50), which catalyzes the first
committed and rate-limiting step in sphingolipid synthesis, is up-regulated in the epidermis …

Publisher Summary This chapter presents the evidence that stratum corneum lipids are
critical effectors of corneocyte cohesion and desquamation. Lipids in the stratum corneum …

Human sebaceous cells, isolated from adult human skin, were cultured on either bovine type
I collagen or mitomycin-C-treated 3T3 fibroblasts. Sebaceous cells, termed “sebocytes” …

Keratinocytes require the essential fatty acid (FA), linoleic acid (LA), for the synthesis of
stratum corneum membrane lipids. A plasma membrane-FA binding protein (PM-FABP), is …

The polyunsaturated fatty acids linoleic acid (18: 2, n-6) and arachidonic acid (20: 4, n-6) are
essential for normal skin function and structure, both as eicosanoid precursors and as …