Recent advances in targeted therapy and immunotherapy have once again raised the hope
that a cure might be within reach for many cancer types. Yet, most late-stage cancers are …

In the past decade, bacteria‐based cancer immunotherapy has attracted much attention in
the academic circle due to its unique mechanism and abundant applications in triggering the …

Precise targeting and high therapeutic efficiency are the major requisites of personalized
cancer treatment. However, some unique features of the tumor microenvironment (TME) …

There is growing interest in the role of microorganisms in human health and disease, with
evidence showing that new types of biotherapy using engineered bacterial therapeutics …

Hypoxia-activated prodrugs (HAPs) are designed to specifically target the hypoxic cells of
tumors, which are an important cause of treatment resistance to conventional therapies …

Drug delivery is a rapidly growing area of research motivated by the nanotechnology
revolution, the ideal of personalized medicine, and the desire to reduce the side effects of …

Genetically engineered bacteria (GEB) have shown significant promises to revolutionize
modern medicine. These engineered bacteria with unique properties such as enhanced …

This review examines the vast catalytic and therapeutic potential offered by type I (ie oxygen-
insensitive) nitroreductase enzymes in partnership with nitroaromatic prodrugs, with …

Traditional methods for cancer therapy, including radiotherapy, chemotherapy, and
immunotherapy are characterized by inherent limitations. Bacteria-mediated tumor therapy …

Clostridium species are both heroes and villains. Some cause serious human and animal
diseases, those present in the gut microbiota generally contribute to health and wellbeing …