Insulin/IGF axis and the Receptor for Advanced Glycation End Products: role in meta-inflammation and potential in cancer therapy

V Vella, R Lappano, E Bonavita, M Maggiolini… - Endocrine …, 2023 - academic.oup.com
In metabolic conditions such as obesity and diabetes, which are associated with
deregulated signaling of the insulin/insulin-like growth factor system (IIGFs), inflammation …

Receptor for advanced glycation end‐products: Biological significance and imaging applications

IT Dobrucki, A Miskalis, M Nelappana… - Wiley …, 2024 - Wiley Online Library
The receptor for advanced glycation end‐products (RAGE or AGER) is a transmembrane,
immunoglobulin‐like receptor that, due to its multiple isoform structures, binds to a diverse …

RAGE inhibitors for targeted therapy of cancer: a comprehensive review

T Faruqui, MS Khan, Y Akhter, S Khan, Z Rafi… - International Journal of …, 2022 - mdpi.com
The receptor for advanced glycation end products (RAGE) is a member of the
immunoglobulin family that is overexpressed in several cancers. RAGE is highly expressed …

The functions and regulatory pathways of S100A8/A9 and its receptors in cancers

H Zhou, C Zhao, R Shao, Y Xu, W Zhao - Frontiers in Pharmacology, 2023 - frontiersin.org
Inflammation primarily influences the initiation, progression, and deterioration of many
human diseases, and immune cells are the principal forces that modulate the balance of …

The role of hyperglycemia in endometrial cancer pathogenesis

FL Byrne, AR Martin, M Kosasih, BT Caruana, R Farrell - Cancers, 2020 - mdpi.com
Endometrial cancer is one of the most common cancers in women worldwide and its
incidence is increasing. Epidemiological evidence shows a strong association between …

Nucleic acids and proteins carried by exosomes of different origins as potential biomarkers for gynecologic cancers

M Ye, J Wang, S Pan, L Zheng, ZW Wang… - Molecular Therapy …, 2022 - cell.com
Exosomes are extracellular vesicles with a diameter of 30–150 nm that function in mediating
intercellular communication and intercellular material exchange. The liposomal membrane …

[HTML][HTML] AGEs and RAGE: Metabolic and molecular signatures of the glycation-inflammation axis in malignant or metastatic cancers

G Palanissami, SFD Paul - Exploration of Targeted Anti-tumor …, 2023 - ncbi.nlm.nih.gov
From attributing mutations to cancers with the advent of cutting-edge genetic technology in
recent decades, to re-searching the age-old theory of intrinsic metabolic shift of cancers …

Therapeutic potential of microalgae-derived bioactive metabolites is influenced by different large-scale culture strategies

J Garcia-Parra, C Fuentes-Grünewald, D Gonzalez - Marine Drugs, 2022 - mdpi.com
Microalgae have been identified as one of the most promising sources of novel bioactive
compounds for biomedical applications, the food industry, and cosmetics. In the last decade …

Advanced glycation end products promote the progression of endometrial cancer via activating the RAGE/CHKA/PI3K/AKT signaling pathway

W Shu, T Hua, X **n, J Zhang, J Lin, R Shi… - …, 2025 - academic.oup.com
Endometrial cancer (EC) is a common malignant tumor that is closely associated with
metabolic disorders such as diabetes and obesity. Advanced glycation end products (AGEs) …

HMGB1 promotes lymphangiogenesis through the activation of RAGE on M2 macrophages in laryngeal squamous cell carcinoma

C Su, S Jia, Z Ma, H Zhang, L Wei, H Liu - Disease Markers, 2022 - Wiley Online Library
Background. Receptor for advanced glycation end products (RAGE) is implicated in tumor
biology. Released high mobility group box protein 1 (HMGB1) ligand binding to RAGE …