The fundamental roles that peptides and proteins play in today's biology makes it almost
indisputable that peptides were key players in the origin of life. Insofar as it is appropriate to …

Protein–protein interactions (PPIs) are involved at all levels of cellular organization, thus
making the development of PPI inhibitors extremely valuable. The identification of selective …

Foldamers are sequence-specific oligomers akin to peptides, proteins and oligonucleotides
that fold into well-defined three-dimensional structures. They offer the chemical biologist a …

For more than a decade now, a search for answers to the following two questions has taken
us on a new and exciting journey into the world of β-and γ-peptides: What happens if the …

The p53-hDM2 protein interaction is a validated therapeutic target in cancer. We report the
synthesis of stabilized alpha-helix of p53 (SAH-p53) compounds that antagonize the p53 …

The principal secondary structural motifs adopted by peptides assembled from β‐amino acid
units are discussed: the 14‐, 12‐, 10‐, 12/10‐, and 8‐helices, as well as the hairpin turn …

The tremendous challenge of inhibiting therapeutically important protein–protein
interactions has created the opportunity to extend traditional medicinal chemistry to a new …

Linear peptides derived from the HIV gp41 C-terminus (C-peptides), such as the 36-residue
Fuzeon, are potent HIV fusion inhibitors. These molecules bind to the N-peptide region of …

Inhibitors of the interaction between the p53 tumor‐suppressor protein and its natural human
inhibitor HDM2 are attractive as potential anticancer agents. In earlier work we explored …

Introduction: Proteins and other biologics comprise emerging therapeutic class with
efficacies against targets for which development of small-molecule antagonists has been …