Successful treatment of cancer depends on early diagnosis and effective monitoring of
patients' response to therapy. Traditional tools based on tumor biopsies lack the sensitivity …

In patients with colorectal cancer (CRC) that metastasizes to the liver, there are several key
goals for improving outcomes including early detection, effective prognostic indicators of …

Circulating nucleic acids are found in free form in body fluids and may serve as minimally
invasive tools for cancer diagnosis and prognosis. Only a few studies have investigated the …

Circulating microRNAs offer attractive potential as epigenetic disease biomarkers by virtue
of their biological stability and ready accessibility in liquid biopsies. Numerous clinical cohort …

Sample collection, processing, storage and isolation methods constitute pre-analytic factors
that can influence the quality of samples used in research and clinical practice. With regard …

Tuberculosis (TB), which is caused by Mycobacterium tuberculosis (Mtb), is one of the most
lethal infectious disease worldwide, and it greatly affects human health. Some diagnostic …

RNAs are rapidly degraded in samples and during collection, processing and testing. In this
study, we used the same method to explore the half-lives of different RNAs and the …

Multiple studies have described extracellular microRNAs (ex-miRNAs) as being remarkably
stable despite the hostile extracellular environment, when stored at 4ºC or lower. Here we …

Prostate cancer (PCa) represents the most commonly diagnosed neoplasm among men.
miRNAs, as biomarkers, could further improve reliability in distinguishing malignant versus …

Circulating small RNAs, including miRNAs but also isomiRs and other RNA species, have
the potential to be used as non-invasive biomarkers for communicable and non …