Dendritic cells (DC) are professional antigen presenting cells, uniquely able to induce naïve
T cell activation and effector differentiation. They are, likewise, involved in the induction and …

Radiotherapy plays a central part in curing cancer. For decades, most research on
improving treatment outcomes has focused on modulating radiation-induced biological …

Recent Developments in Radiotherapy | New England Journal of Medicine Skip to main content
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The recent success of cancer immunotherapy has demonstrated the power of the immune
system to clear tumors, generating renewed enthusiasm for identifying ways to induce …

Approximately one‐half of patients with newly diagnosed cancer and many patients with
persistent or recurrent tumors receive radiotherapy (RT), with the explicit goal of eliminating …

Radiotherapy (RT) used at immunogenic doses leads to accumulation of cytosolic double-
stranded DNA (dsDNA) in cancer cells, which activates type I IFN (IFN-I) via the cGAS/STING …

Increasing evidence demonstrates that radiation acts as an immune stimulus, recruiting
immune mediators that enable anti-tumor responses within and outside the radiation field …

The therapeutic application of ionizing radiation has been largely based on its cytocidal
power combined with the ability to selectively target tumors. Radiotherapy effects on survival …

Therapeutic vaccines represent a viable option for active immunotherapy of cancers that aim
to treat late stage disease by using a patient's own immune system. The promising results …

Purpose: This study tested the hypothesis that the type of dose fractionation regimen
determines the ability of radiotherapy to synergize with anti–CTLA-4 antibody. Experimental …