Preterm prelabor rupture of the membranes (pPROM) remains a significant obstetric
problem that affects 3–4% of all pregnancies and precedes 40–50% of all preterm births …

Stress and stress hormones, glucocorticoids (GCs), exert widespread actions in central
nervous system, ranging from the regulation of gene transcription, cellular signaling …

Senescent cells (SCs) have been considered a source of age-related chronic sterile
systemic inflammation and a target for anti-aging therapies. To understand mechanisms …

Biological aging is characterized by a chronic low-grade inflammation level. This chronic
phenomenon has been named “inflamm-aging” and is a highly significant risk factor for …

Early adversity, in the form of abuse, neglect, socioeconomic status and other adverse
experiences, is associated with poor physical and mental health outcomes. To understand …

Chronic kidney disease (CKD) shares many phenotypic similarities with other chronic
diseases, including heart failure, chronic obstructive pulmonary disease, HIV infection and …

Residents of distressed urban areas suffer early aging-related disease and excess mortality.
Using a community-based participatory research approach in a collaboration between social …

We hypothesize that black women experience accelerated biological aging in response to
repeated or prolonged adaptation to subjective and objective stressors. Drawing on stress …

Background Depression is associated with an unusually high rate of aging-related illnesses
and early mortality. One aspect of “accelerated aging” in depression may be shortened …

Background Leukocyte telomere length (LTL) is an indicator of general systemic aging, with
shorter LTL being associated with several chronic diseases of aging and earlier mortality …