Salmonella Pathogenicity Island 1 (SPI-1) and Its Complex Regulatory Network

L Lou, P Zhang, R Piao, Y Wang - Frontiers in cellular and infection …, 2019 - frontiersin.org
Salmonella species can infect a diverse range of birds, reptiles, and mammals, including
humans. The type III protein secretion system (T3SS) encoded by Salmonella pathogenicity …

[HTML][HTML] Salmonella effector driven invasion of the gut epithelium: breaking in and setting the house on fire

SA Fattinger, ME Sellin, WD Hardt - Current Opinion in Microbiology, 2021 - Elsevier
Highlights•IEC invasion is a crucial step in the life cycle of non-typhoidal Salmonella.•TTSS-
1 effectors SopE/E2 and particularly SipA mediate IEC invasion in mice.•Entry structures …

Dual RNA-seq unveils noncoding RNA functions in host–pathogen interactions

AJ Westermann, KU Förstner, F Amman, L Barquist… - Nature, 2016 - nature.com
Bacteria express many small RNAs for which the regulatory roles in pathogenesis have
remained poorly understood due to a paucity of robust phenotypes in standard virulence …

[HTML][HTML] Salmonella Typhimurium reprograms macrophage metabolism via T3SS effector SopE2 to promote intracellular replication and virulence

L Jiang, P Wang, X Song, H Zhang, S Ma… - Nature …, 2021 - nature.com
Salmonella Typhimurium establishes systemic infection by replicating in host macrophages.
Here we show that macrophages infected with S. Typhimurium exhibit upregulated …

Salmonella Virulence and Immune Escape

M Wang, IH Qazi, L Wang, G Zhou, H Han - Microorganisms, 2020 - mdpi.com
Salmonella genus represents the most common foodborne pathogens causing morbidity,
mortality, and burden of disease in all regions of the world. The introduction of antimicrobial …

The ubiquitin system: a critical regulator of innate immunity and pathogen–host interactions

J Li, QY Chai, CH Liu - Cellular & molecular immunology, 2016 - nature.com
The ubiquitin system comprises enzymes that are responsible for ubiquitination and
deubiquitination, as well as ubiquitin receptors that are capable of recognizing and …

Prophages in Salmonella enterica: a driving force in resha** the genome and physiology of their bacterial host?

A Wahl, A Battesti, M Ansaldi - Molecular microbiology, 2019 - Wiley Online Library
Thanks to the exponentially increasing number of publicly available bacterial genome
sequences, one can now estimate the important contribution of integrated viral sequences to …

Minimal SPI1-T3SS effector requirement for Salmonella enterocyte invasion and intracellular proliferation in vivo

K Zhang, A Riba, M Nietschke, N Torow… - PLoS …, 2018 - journals.plos.org
Effector molecules translocated by the Salmonella pathogenicity island (SPI) 1-encoded
type 3 secretion system (T3SS) critically contribute to the pathogenesis of human …

Speaking the host language: how Salmonella effector proteins manipulate the host

TD Pillay, SU Hettiarachchi, J Gan… - …, 2023 - microbiologyresearch.org
Salmonella injects over 40 virulence factors, termed effectors, into host cells to subvert
diverse host cellular processes. Of these 40 Salmonella effectors, at least 25 have been …

SopF, a phosphoinositide binding effector, promotes the stability of the nascent Salmonella-containing vacuole

N Lau, AL Haeberle, BJ O'Keeffe, EA Latomanski… - PLoS …, 2019 - journals.plos.org
The enteric bacterial pathogen Salmonella enterica serovar Typhimurium (S. Typhimurium),
utilizes two type III secretion systems (T3SSs) to invade host cells, survive and replicate …