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An updated review on 1, 2, 3-/1, 2, 4-triazoles: synthesis and diverse range of biological potential
The synthesis of triazoles has attracted a lot of interest in the field of organic chemistry
because of its versatile chemical characteristics and possible biological uses. This review …
because of its versatile chemical characteristics and possible biological uses. This review …
The anti‐breast cancer therapeutic potential of 1, 2, 3‐triazole‐containing hybrids
J Song, S Zhang, B Zhang, J Ma - Archiv der Pharmazie, 2024 - Wiley Online Library
Breast cancer, as one of the most common invasive malignancies and the leading cause of
cancer‐related deaths in women globally, poses a significant challenge in the world health …
cancer‐related deaths in women globally, poses a significant challenge in the world health …
Molecular hybrids based on 1, 2, 3-triazole and 1, 3, 4-thiadiazole cores: Synthesis, characterization, anticancer activity and in silico study
Abstract One sets of 1, 3, 4-thiadiazole analogs 14a-c and 15a-c were synthesized by the
incorporation of two heterocyclic nuclei (1, 2, 3-triazole & 1, 3, 4-thiadiazoles) in objective of …
incorporation of two heterocyclic nuclei (1, 2, 3-triazole & 1, 3, 4-thiadiazoles) in objective of …
New 1, 2, 3-triazoles from (R)-carvone: Synthesis, DFT mechanistic study and in vitro cytotoxic evaluation
A Oubella, A Bimoussa, A N'ait Oussidi, M Fawzi… - Molecules, 2022 - mdpi.com
Aseries of novel 1, 4-disubstituted 1, 2, 3-triazoles were synthesized from an (R)-carvone
terminal alkyne derivative via a Cu (I)-catalyzed azide–alkyne cycloaddition reaction using …
terminal alkyne derivative via a Cu (I)-catalyzed azide–alkyne cycloaddition reaction using …
Click reaction inspired synthesis, antimicrobial evaluation and in silico docking of some pyrrole-chalcone linked 1, 2, 3-triazole hybrids
The discovery of small organic molecules as new antimicrobial agents is a promising
strategy for encountering the problem of multidrug-resistant microbial strains. In an attempt …
strategy for encountering the problem of multidrug-resistant microbial strains. In an attempt …
Hybrids of thiazolidinone with 1,2,3-triazole derivatives: design, synthesis, biological evaluation, in silico studies, molecular docking, molecular dynamics simulations …
A new series of thiazolidinone linked 1, 2, 3-triazole hybrids 5a-h was designed and
synthesized using the copper-catalyzed Huisgen azide-alkyne cycloaddition (CuAAC) …
synthesized using the copper-catalyzed Huisgen azide-alkyne cycloaddition (CuAAC) …
Design, synthesis, cytotoxic effect evaluation and molecular docking of (R)‐camphor‐based thiazolidinone‐isoxazole and thiazolidinone‐1, 2, 3‐triazole hybrids “
AN Ousidi, A Bimoussa, M Loubidi, M Fawzi… - …, 2023 - Wiley Online Library
A variety of hybrid compounds, combining a camphor thiazolidinone skeleton with either 1,
2, 3‐triazole or isoxazole nucleus, have been synthesized from natural (R)‐camphor. Our …
2, 3‐triazole or isoxazole nucleus, have been synthesized from natural (R)‐camphor. Our …
Hybrid of the 1, 2, 3‐triazole nucleus and sesquiterpene skeleton as a potential antitumor agent: Hemisynthesis, molecular structure, Hirshfeld surface analysis …
Abstract A new 1, 2, 3‐triazole sesquiterpenic named (4aR, 5aS, 7aR, 10aR, 10bR)‐10‐
benzyl‐5, 5‐dichloro‐1, 1, 4a, 7a‐tetramethyl‐1, 2, 3, 4, 4a, 5, 7a, 10, 10a, 10b …
benzyl‐5, 5‐dichloro‐1, 1, 4a, 7a‐tetramethyl‐1, 2, 3, 4, 4a, 5, 7a, 10, 10a, 10b …
Design, synthesis, evaluation of new 3-acetylisoxazolines and their hybrid analogous as anticancer agents: in vitro and in silico analysis
Acetylisoxazolines were synthesized by the reaction of natural (R)-limonene and (R)-
carvone with acetone in the presence of iron (III) nitrate. The reaction showed to be highly …
carvone with acetone in the presence of iron (III) nitrate. The reaction showed to be highly …
Discovery of a new Bcl-2 inhibitor through synthesis, anticancer activity, docking and MD simulations
S Byadi, B Abdoullah, M Fawzi, E Irrou… - Journal of …, 2024 - Taylor & Francis
A database of 300 compounds was virtually screened and docked against Bcl-2 protein; the
stability of the best-formed complex was evaluated through Molecular dynamics, the top ten …
stability of the best-formed complex was evaluated through Molecular dynamics, the top ten …