Cerebral amyloid angiopathy and Alzheimer disease—one peptide, two pathways
The shared role of amyloid-β (Aβ) deposition in cerebral amyloid angiopathy (CAA) and
Alzheimer disease (AD) is arguably the clearest instance of crosstalk between …
Alzheimer disease (AD) is arguably the clearest instance of crosstalk between …
Traumatic brain injury and Alzheimer's disease: the cerebrovascular link
J Ramos-Cejudo, T Wisniewski, C Marmar… - …, 2018 - thelancet.com
Traumatic brain injury (TBI) and Alzheimer's disease (AD) are devastating neurological
disorders, whose complex relationship is not completely understood. Cerebrovascular …
disorders, whose complex relationship is not completely understood. Cerebrovascular …
Neurovascular pathways to neurodegeneration in Alzheimer's disease and other disorders
BV Zlokovic - Nature Reviews Neuroscience, 2011 - nature.com
The neurovascular unit (NVU) comprises brain endothelial cells, pericytes or vascular
smooth muscle cells, glia and neurons. The NVU controls blood–brain barrier (BBB) …
smooth muscle cells, glia and neurons. The NVU controls blood–brain barrier (BBB) …
The hCMEC/D3 cell line as a model of the human blood brain barrier
B Weksler, IA Romero, PO Couraud - Fluids and Barriers of the CNS, 2013 - Springer
Since the first attempts in the 1970s to isolate cerebral microvessel endothelial cells (CECs)
in order to model the blood–brain barrier (BBB) in vitro, the need for a human BBB model …
in order to model the blood–brain barrier (BBB) in vitro, the need for a human BBB model …
Vascular dysfunction in Alzheimer's disease: a prelude to the pathological process or a consequence of it?
K Govindpani, LG McNamara, NR Smith… - Journal of clinical …, 2019 - mdpi.com
Alzheimer's disease (AD) is the most prevalent form of dementia. Despite decades of
research following several theoretical and clinical lines, all existing treatments for the …
research following several theoretical and clinical lines, all existing treatments for the …
Amyloid triggers extensive cerebral angiogenesis causing blood brain barrier permeability and hypervascularity in Alzheimer's disease
Evidence of reduced blood-brain barrier (BBB) integrity preceding other Alzheimer's disease
(AD) pathology provides a strong link between cerebrovascular angiopathy and AD …
(AD) pathology provides a strong link between cerebrovascular angiopathy and AD …
Neurovascular dysfunction and faulty amyloid β-peptide clearance in Alzheimer disease
AP Sagare, RD Bell… - Cold Spring …, 2012 - perspectivesinmedicine.cshlp.org
Neurovascular dysfunction is an integral part of Alzheimer disease (AD). Changes in the
brain vascular system may contribute in a significant way to the onset and progression of …
brain vascular system may contribute in a significant way to the onset and progression of …
Familial Alzheimer's disease mutations within the amyloid precursor protein alter the aggregation and conformation of the amyloid-β peptide
Most cases of Alzheimer's disease (AD) are sporadic, but a small percentage of AD cases,
called familial AD (FAD), are associated with mutations in presenilin 1, presenilin 2, or the …
called familial AD (FAD), are associated with mutations in presenilin 1, presenilin 2, or the …
Dissecting the crosstalk between endothelial mitochondrial damage, vascular inflammation, and neurodegeneration in cerebral amyloid angiopathy and Alzheimer's …
Alzheimer's disease (AD) is the most prevalent cause of dementia and is pathologically
characterized by the presence of parenchymal senile plaques composed of amyloid β (Aβ) …
characterized by the presence of parenchymal senile plaques composed of amyloid β (Aβ) …
Vascular β-amyloid and early astrocyte alterations impair cerebrovascular function and cerebral metabolism in transgenic arcAβ mice
M Merlini, EP Meyer, A Ulmann-Schuler… - Acta neuropathologica, 2011 - Springer
Cerebrovascular lesions related to congophilic amyloid angiopathy (CAA) often accompany
deposition of β-amyloid (Aβ) in Alzheimer's disease (AD), leading to disturbed cerebral …
deposition of β-amyloid (Aβ) in Alzheimer's disease (AD), leading to disturbed cerebral …