The reaction takes place at a specialized metal center that dramatically increases the acidity
of H2 and leads to a heterolytic splitting of the molecule which is strongly accelerated by the …

If the atmosphere of the early Earth was hydrogen-rich, 1 it is reasonable to think that
hydrogenases, the enzymes enabling cells to use molecular hydrogen, were probably …

The utilization of hydrogen by micro-organisms as a source of reducing power or of protons
as final electron acceptors is mediated by metalloenzymes called hydrogenases. The need …

Abstract The [FeFe]-and [NiFe]-hydrogenases catalyze the formal interconversion between
hydrogen and protons and electrons, possess characteristic non-protein ligands at their …

Most methanogenic archaea reduce CO2 with H2 to CH4. For the activation of H2, they use
different [NiFe]-hydrogenases, namely energy-converting [NiFe]-hydrogenases …

Hydrogen, the most abundant element in the Universe, is considered to be an environmental
friendly energy carrier because its combustion generates water. Nowadays, owing to the …

Cyanobacteria may possess two distinct nickel-iron (NiFe)-hydrogenases: an uptake
enzyme found in N 2-fixing strains, and a bidirectional one present in both non-N 2-fixing …

Maturation of [FeFe] hydrogenases requires the biosynthesis and insertion of the catalytic
iron-sulfur cluster, the H cluster. Two radical S-adenosylmethionine (SAM) proteins …

Enzymes possessing the capacity to oxidize molecular hydrogen have developed
convergently three class of enzymes leading to:[FeFe]-,[NiFe]-, and [FeS]-cluster-free …

Nickel is an essential catalytic cofactor of enzymes found in eubacteria, archaebacteria,
fungi, and plants. 1-6 These enzymes catalyze a diverse array of reactions that include both …