Non-alcoholic fatty liver disease (NAFLD), currently the leading cause of global chronic liver
disease, has emerged as a major public health problem, more efficient therapeutics of which …

Adipose tissue exhibits remarkable plasticity with capacity to change in size and cellular
composition under physiological and pathophysiological conditions. The emergence of …

The proliferator-activated receptor γ (PPARγ), a member of the nuclear receptor superfamily,
is one of the most extensively studied ligand-inducible transcription factors. Since its …

Obesity is a metabolic state generated by the expansion of adipose tissue. Adipose tissue
expansion depends on the interplay between hyperplasia and hypertrophy, and is mainly …

Adipogenesis is the process by which precursor stem cells differentiate into lipid laden
adipocytes. Adipogenesis is regulated by a complex and highly orchestrated gene …

The NAD+-dependent deacetylase SIRT1 controls key metabolic functions by deacetylating
target proteins and strategies that promote SIRT1 function such as SIRT1 overexpression or …

Ferroptosis is an iron‐dependent form of non‐apoptotic cell death implicated in liver, brain,
kidney, and heart pathology. How ferroptosis is regulated remains poorly understood. Here …

A wealth of specialized cell populations within the skin facilitates its hair-producing,
protective, sensory, and thermoregulatory functions. How the vast cell-type diversity and …

Fatty acid trafficking in cells affects many aspects of cellular function3). Fatty acids act both
as an energy source and as signals for metabolic regulations including gene expression …

Agonists of the nuclear receptor PPARγ are therapeutically used to combat hyperglycaemia
associated with the metabolic syndrome and type 2 diabetes. In spite of being effective in …