Cognitive and behavioural flexibility permit the appropriate adjustment of thoughts and
behaviours in response to changing environmental demands. Brain mechanisms enabling …

Most patients with Alzheimer's disease present with amnestic problems; however, a
substantial proportion, over-represented in young-onset cases, have atypical phenotypes …

Frontotemporal lobar degeneration (FTLD) is one of the most common causes of early-onset
dementia and presents with early social–emotional–behavioural and/or language changes …

Alzheimer disease (AD) is biologically defined by the presence of β-amyloid-containing
plaques and tau-containing neurofibrillary tangles. AD is a genetic and sporadic …

PURPOSE OF REVIEW This article summarizes the cognitive and behavioral functions of
the prefrontal cortex with an emphasis on executive cognitive functions and the clinical …

Early-onset Alzheimer's disease (EOAD) is a rare but particularly devastating form of AD.
Though notable for its high degree of clinical heterogeneity, EOAD is defined by the same …

Importance The behavioral variant of Alzheimer disease (bvAD) is characterized by early
and predominant behavioral deficits caused by AD pathology. This AD phenotype is …

Disruption of mental functions in Alzheimer's disease (AD) and related disorders is
accompanied by selective degeneration of brain regions. These regions comprise large …

Abstract Alzheimer's disease (AD), the most common form of dementia worldwide, is a mixed
proteinopathy (β-amyloid, tau and other proteins). Classically defined as a …

Objective To assess whether Alzheimer disease (AD) clinical presentation and APOE4
relate to the burden and topography of β-amyloid (Aβ) and tau pathologies using in vivo PET …