C–H deuteration of organic compounds and potential drug candidates

G Prakash, N Paul, GA Oliver, DB Werz… - Chemical Society …, 2022 - pubs.rsc.org
C–H deuteration has been intricately developed to satisfy the urgent need for site-selectively
deuterated organic frameworks. Deuteration has been primarily used to study kinetic isotope …

The Suzuki-Miyaura reaction after the Nobel prize

IP Beletskaya, F Alonso, V Tyurin - Coordination Chemistry Reviews, 2019 - Elsevier
Synthetic organic chemistry experienced a significant advance in the last quarter of the 20th
century with the advent of the transition-metal catalyzed cross-coupling reactions. The utility …

C–H Functionalization of Pyridines via Oxazino Pyridine Intermediates: Switching to para-Selectivity under Acidic Conditions

H Cao, D Bhattacharya, Q Cheng… - Journal of the American …, 2023 - ACS Publications
para-Selective C–H functionalization of pyridines holds a significant value but remains
underdeveloped. Site-switchable C–H functionalization of pyridines under easily tunable …

Recent advances in metal‐catalyzed functionalization of indoles

K Urbina, D Tresp, K Sipps… - Advanced Synthesis & …, 2021 - Wiley Online Library
Indole is one of the most important heterocycles in organic synthesis, natural products, and
drug discovery. Recently, tremendous advances in the selective functionalization of indoles …

The chemistry of heterocycles in the 21st century

VN Charushin, EV Verbitskiy, ON Chupakhin… - Uspekhi Khimii, 2024 - mathnet.ru
The chemistry of heterocyclic compounds has traditionally been and remains a bright area of
chemical science in Russia. This is due to the fact that many heterocycles find the widest …

Benefits and applications of microwave-assisted synthesis of nitrogen containing heterocycles in medicinal chemistry

M Henary, C Kananda, L Rotolo, B Savino, EA Owens… - RSC …, 2020 - pubs.rsc.org
Nitrogen containing heterocycles are of immense research interest because they are often
found as naturally occurring bioactive compounds. The prominence of N-heterocycles …

Visible-light-induced [3+ 2] cycloadditions of donor/donor diazo intermediates with alkenes to achieve (spiro)-pyrazolines and pyrazoles

Y Zhang, Y Li, SF Ni, JP Li, D **a, X Han, J Lin… - Chemical …, 2023 - pubs.rsc.org
To date,[3+ 2] cycloadditions of diazo esters with alkynes or alkenes have been a robust tool
to generate pyrazoles and pyrazolines. However, methods capable of generating …

Achmatowicz rearrangement-inspired development of green chemistry, organic methodology, and total synthesis of natural products

L Liang, LD Guo, R Tong - Accounts of Chemical Research, 2022 - ACS Publications
Conspectus The six-membered heterocycles containing oxygen and nitrogen
(tetrahydropyrans, pyrans, piperidines) are among the most common heterocyclic structures …

Molecular editing of pyrroles via a skeletal recasting strategy

X Zhou, Q Huang, J Guo, L Dai, Y Lu - ACS Central Science, 2023 - ACS Publications
Heterocyclic scaffolds are commonly found in numerous biologically active molecules,
therapeutic agents, and agrochemicals. To probe chemical space around heterocycles …

[HTML][HTML] Recent developments using malononitrile in ultrasound-assisted multicomponent synthesis of heterocycles

R Javahershenas, S Nikzat - Ultrasonics Sonochemistry, 2024 - Elsevier
Ultrasonic irradiation serves as a vigorous and environmentally sustainable approach for
augmenting multicomponent reactions (MCRs), offering benefits such as thermal …