Genes regulating spermatogenesis and sperm function associated with rare disorders

E Linn, L Ghanem, H Bhakta, C Greer… - Frontiers in Cell and …, 2021 - frontiersin.org
Spermatogenesis is a cell differentiation process that ensures the production of fertilizing
sperm, which ultimately fuse with an egg to form a zygote. Normal spermatogenesis relies …

Everything you ever wanted to know about PKA regulation and its involvement in mammalian sperm capacitation

CB Graf, C Ritagliati, C Stival, GM Luque… - Molecular and Cellular …, 2020 - Elsevier
Abstract The 3′, 5′-cyclic adenosine monophosphate (cAMP) dependent protein kinase
(PKA) is a tetrameric holoenzyme comprising a set of two regulatory subunits (PKA-R) and …

Altered G-protein transduction protein gene expression in the testis of infertile patients with nonobstructive azoospermia

D Hashemi Karoii, H Azizi, T Skutella - DNA and Cell Biology, 2023 - liebertpub.com
Recent studies have shown that several members of the G-protein-coupled receptors
(GPCR) superfamily play crucial roles in the maintenance of ion–water homeostasis of the …

Proteomics of human spermatozoa

J Castillo, A de la Iglesia, M Leiva, M Jodar… - Human …, 2023 - academic.oup.com
Proteomic methodologies offer a robust approach to identify and quantify thousands of
proteins from semen components in both fertile donors and infertile patients. These …

Proteomic Changes in Human Sperm During Sequential in vitro Capacitation and Acrosome Reaction

J Castillo, OA Bogle, M Jodar, F Torabi… - Frontiers in Cell and …, 2019 - frontiersin.org
The male gamete is not completely mature after ejaculation and requires further events in
the female genital tract to acquire fertilizing ability, including the processes of capacitation …

Protein acetylation protects sperm from spontaneous acrosome reaction

Z Bowker, S Goldstein, H Breitbart - Theriogenology, 2022 - Elsevier
In order to penetrate the egg, spermatozoa must undergo the acrosome reaction in close
proximity to the egg. This process can take place only after a series of biochemical changes …

Involvement of metabolic pathway in the sperm spontaneous acrosome reaction

T Dahan, H Breitbart - Theriogenology, 2022 - Elsevier
In order to fertilize the egg, spermatozoa must undergo a series of biochemical processes in
the female reproductive tract collectively called capacitation. Only capacitated sperm can …

Metabolite Support of Long-Term Storage of Sperm in the Spermatheca of Honeybee (Apis mellifera) Queens

Z Liu, F Liu, G Li, X Chi, Y Wang, H Wang, L Ma… - Frontiers in …, 2020 - frontiersin.org
The polyandrous mating system of honeybees (Apis mellifera L.) has garnered widespread
attention. Long-lived honeybee queens only mate early in maturation, and the sperm …

[HTML][HTML] Citrate promotes nitric oxide production during human sperm capacitation

D Loggia, C O'Flaherty - Antioxidants, 2024 - mdpi.com
Sperm capacitation is a complex process essential for the spermatozoon to recognize and
fertilize the oocyte. For capacitation to occur, human spermatozoa require low levels of …

Mechanisms that protect mammalian sperm from the spontaneous acrosome reaction

H Breitbart, E Grinshtein - International Journal of Molecular Sciences, 2023 - mdpi.com
To acquire the capacity to fertilize the oocyte, mammalian spermatozoa must undergo a
series of biochemical reactions in the female reproductive tract, which are collectively called …