Although the oral route is the most convenient route for drug administration, there are a
number of circumstances where this is not possible from either a clinical or pharmaceutical …

A significant proportion of recently approved drug molecules possess poor aqueous
solubility which further restrains their desired bioavailability. Poor aqueous solubility of these …

Ulcerative colitis is a global health problem, affecting millions of individuals worldwide. As
an inflammatory condition localised in the large intestine, rectal delivery of …

Poorly water‐soluble drug candidates are becoming more prevalent. It has been estimated
that approximately 60–70% of the drug molecules are insufficiently soluble in aqueous …

The rectal route is an effective route for the local and systemic delivery of active
pharmaceutical ingredients. The environment of the rectum is relatively constant with low …

Acute severe ulcerative colitis (ASUC) is a growing health burden that often requires
treatment with multiple therapeutic agents. As inflammation is localised in the rectum and …

The rectal route can be considered a good alternative to the oral route for the paediatric
population because these dosage forms are neither to be swallowed nor need to be taste …

In vitro dissolution/release tests are an important tool in the drug product development
phase as well as in its quality control and the regulatory approval process. Mucosal drug …

Malaria is an infectious disease that mainly affects children and pregnant women from
tropical countries. The mortality rate of people infected with malaria per year is enormous …

Nasal delivery has become a growing area of interest for drug administration as a
consequence of several practical advantages, such as ease of administration and non …