The re-emergence of natural products for drug discovery in the genomics era

AL Harvey, RA Edrada-Ebel, RJ Quinn - Nature reviews drug discovery, 2015 - nature.com
Natural products have been a rich source of compounds for drug discovery. However, their
use has diminished in the past two decades, in part because of technical barriers to …

Microbiology, genomics, and clinical significance of the Pseudomonas fluorescens species complex, an unappreciated colonizer of humans

BS Scales, RP Dickson, JJ LiPuma… - Clinical microbiology …, 2014 - journals.asm.org
Pseudomonas fluorescens is not generally considered a bacterial pathogen in humans;
however, multiple culture-based and culture-independent studies have identified it at low …

[KNIHA][B] What are bacterial extracellular polymeric substances?

J Wingender, TR Neu, HC Flemming - 1999 - Springer
The vast majority of microorganisms live and grow in aggregated forms such as biofilms and
flocs (“planktonic biofilms”). This mode of existence is lumped in the somewhat inexact but …

Type III protein secretion systems in bacterial pathogens of animals and plants

CJ Hueck - Microbiology and molecular biology reviews, 1998 - journals.asm.org
Various gram-negative animal and plant pathogens use a novel, sec-independent protein
secretion system as a basic virulence mechanism. It is becoming increasingly clear that …

cag, a pathogenicity island of Helicobacter pylori, encodes type I-specific and disease-associated virulence factors

S Censini, C Lange, Z **ang, JE Crabtree… - Proceedings of the …, 1996 - pnas.org
cagA, a gene that codes for an immunodominant antigen, is present only in Helicobacter
pylori strains that are associated with severe forms of gastroduodenal disease (type I …

Bacterial biocatalysts: molecular biology, three-dimensional structures, and biotechnological applications of lipases

KE Jaeger, BW Dijkstra, MT Reetz - Annual Reviews in …, 1999 - annualreviews.org
▪ Abstract Bacteria produce and secrete lipases, which can catalyze both the hydrolysis and
the synthesis of long-chain acylglycerols. These reactions usually proceed with high …

Common themes in microbial pathogenicity revisited

BB Finlay, S Falkow - Microbiology and molecular biology reviews, 1997 - journals.asm.org
Bacterial pathogens employ a number of genetic strategies to cause infection and,
occasionally, disease in their hosts. Many of these virulence factors and their regulatory …

The physiology and biochemistry of prokaryotes

D White, JT Drummond, C Fuqua - 1995 - scholar.archive.org
While many textbooks are available for introducing microbiology at the college level, and
collections reviewing the latest research in specifıc organisms or environments are …

[HTML][HTML] Type 3 secretion system of Pseudomonas aeruginosa

G Horna, J Ruiz - Microbiological Research, 2021 - Elsevier
Pseudomonas aeruginosa is an opportunistic pathogen, mainly affecting severe patients,
such as those in intensive care units (ICUs). High levels of antibiotic resistance and a long …

ATP-binding cassette transporters in bacteria

AL Davidson, J Chen - Annual review of biochemistry, 2004 - annualreviews.org
▪ Abstract ATP-binding cassette (ABC) transporters couple ATP hydrolysis to the uptake and
efflux of solutes across the cell membrane in bacteria and eukaryotic cells. In bacteria, these …