Pulmonary fibrosis as a result of acute lung inflammation: molecular mechanisms, relevant in vivo models, prognostic and therapeutic approaches

IA Savin, MA Zenkova, AV Sen'kova - International journal of molecular …, 2022 - mdpi.com
Pulmonary fibrosis is a chronic progressive lung disease that steadily leads to lung
architecture disruption and respiratory failure. The development of pulmonary fibrosis is …

[HTML][HTML] Diagnosis and treatment of acute pulmonary inflammation in critically ill patients: the role of inflammatory biomarkers

S Chalmers, A Khawaja, PM Wieruszewski… - World journal of …, 2019 - ncbi.nlm.nih.gov
Pneumonia and acute respiratory distress syndrome are common and important causes of
respiratory failure in the intensive care unit with a significant impact on morbidity, mortality …

[HTML][HTML] β-Glucan extracts from the same edible shiitake mushroom Lentinus edodes produce differential in-vitro immunomodulatory and pulmonary cytoprotective …

EJ Murphy, C Masterson, E Rezoagli, D O'Toole… - Science of the Total …, 2020 - Elsevier
Coronavirus pneumonia is accompanied by rapid virus replication, where a large number of
inflammatory cell infiltration and cytokine storm may lead to acute lung injury, acute …

Epidemiology, mechanical power, and 3-year outcomes in acute respiratory distress syndrome patients using standardized screening. An observational cohort study

KKS Parhar, K Zjadewicz, A Soo, A Sutton… - Annals of the …, 2019 - atsjournals.org
Rationale: Limited data on the epidemiology of acute respiratory distress syndrome (ARDS)
using a standardized screening program exist. Objectives: To describe the population-based …

COVID-19-related ARDS: key mechanistic features and treatments

J Selickman, CS Vrettou, SD Mentzelopoulos… - Journal of clinical …, 2022 - mdpi.com
Acute respiratory distress syndrome (ARDS) is a heterogeneous syndrome historically
characterized by the presence of severe hypoxemia, high-permeability pulmonary edema …

Immunomodulatory activity of β-glucan polysaccharides isolated from different species of mushroom–A potential treatment for inflammatory lung conditions

EJ Murphy, E Rezoagli, R Pogue… - Science of the Total …, 2022 - Elsevier
Acute respiratory distress syndrome (ARDS) is the most common form of acute severe
hypoxemic respiratory failure in the critically ill with a hospital mortality of 40%. Alveolar …

New insights into clinical and mechanistic heterogeneity of the acute respiratory distress syndrome: summary of the Aspen Lung Conference 2021

TR Martin, RL Zemans, LB Ware… - American journal of …, 2022 - atsjournals.org
Clinical and molecular heterogeneity are common features of human disease.
Understanding the basis for heterogeneity has led to major advances in therapy for many …

A potential new pathway for heparin treatment of sepsis-induced lung injury: inhibition of pulmonary endothelial cell pyroptosis by blocking hMGB1-LPS-induced …

R Yang, X Zhang - Frontiers in Cellular and Infection Microbiology, 2022 - frontiersin.org
Sepsis is a significant cause of mortality in critically ill patients. Acute lung injury (ALI) is a
leading cause of death in these patients. Endothelial cells exposed to the bacterial …

[HTML][HTML] Antibiotics as immunomodulators: a potential pharmacologic approach for ARDS treatment

A Sauer, K Peukert, C Putensen… - European Respiratory …, 2021 - Eur Respiratory Soc
First described in the mid-1960s, acute respiratory distress syndrome (ARDS) is a life-
threatening form of respiratory failure with an overall mortality rate of approximately 40 …

Advancing precision medicine for the diagnosis and treatment of acute respiratory distress syndrome

AN Rizzo, NR Aggarwal, BT Thompson… - Journal of Clinical …, 2023 - mdpi.com
Acute respiratory distress syndrome (ARDS) is a common and life-threatening cause of
respiratory failure. Despite decades of research, there are no effective pharmacologic …