Results Thirty-four studies (25 cross-sectional, n= 2095; nine cohort, n= 991) were included.
The overall risk of bias was high because of selection and measurement biases. The global …

Chronic kidney disease (CKD) affects more than 37 million American adults. Adult-onset
CKD is typically attributed to acquired comorbidities such as aging, type II diabetes, and …

Background The gut–kidney axis is implicated in chronic kidney disease (CKD) morbidity.
We describe how a panel of gut microbiome–derived toxins relates to kidney function and …

Purpose To investigate the pathophysiologic effects of chronic kidney disease (CKD) on
brain function in children with CKD by correlating cerebral blood flow (CBF) with clinical and …

Background: Children with chronic kidney disease (CKD) are at risk for impaired
neurocognitive functioning. We investigated metabolomic associations with neurocognition …

Dialysis treatment has evolved to enable children to live longer and transition to adulthood.
Thus, the focus of care shifts to a consideration of pediatric patients' quality of life and …

Acute kidney injury (AKI) occurs in nearly 30% of sick neonates. Chronic kidney disease
(CKD) can be detected in certain populations of sick neonates as early as 2 years. AKI is …

Background The neuroanatomic basis for cognitive impairment in chronic kidney disease
(CKD) is incompletely characterized. We performed advanced quantitative structural …

Cross-talk is broadly defined as endogenous homeostatic signaling between vital organs
such as the heart, kidneys and brain. Kidney–brain cross-talk remains an area with …

Background Cognitive functions are altered in patients with CKD. However, it is suggested
that cognitive functions improve after kidney transplantation, at least partially. A possible …