Augmenting regulatory T cells: new therapeutic strategy for rheumatoid arthritis

J Zhang, H Liu, Y Chen, H Liu, S Zhang, G Yin… - Frontiers in …, 2024 - frontiersin.org
Rheumatoid arthritis (RA) is a chronic, systemic autoimmune condition marked by
inflammation of the joints, degradation of the articular cartilage, and bone resorption. Recent …

Regulatory T cells: masterminds of immune equilibrium and future therapeutic innovations

J Ge, X Yin, L Chen - Frontiers in Immunology, 2024 - frontiersin.org
Regulatory T cells (Tregs), a subset of CD4+ T cells marked by the expression of the
transcription factor forkhead box protein 3 (Foxp3), are pivotal in maintaining immune …

Harnessing the biology of regulatory T cells to treat disease

CM Wardell, DA Boardman, MK Levings - Nature Reviews Drug …, 2024 - nature.com
Regulatory T (T reg) cells are a suppressive subset of CD4+ T cells that maintain immune
homeostasis and restrain inflammation. Three decades after their discovery, the promise of …

A comprehensive overview of tolerogenic vaccine adjuvants and their modes of action

S Arve-Butler, CD Moorman - Frontiers in Immunology, 2024 - frontiersin.org
Tolerogenic vaccines represent a therapeutic approach to induce antigen-specific immune
tolerance to disease-relevant antigens. As general immunosuppression comes with …

Comparison of emulsion and spray methods for fabrication of rapamycin-loaded acetalated dextran microparticles

SA Ehrenzeller, NR Lukesh, RT Stiepel… - RSC …, 2024 - pubs.rsc.org
Rapamycin (rapa), an immunosuppressive medication, has demonstrated considerable
effectiveness in reducing organ transplant rejection and treating select autoimmune …