Trans-Splicing in Trypanosomes: Machinery and Its Impact on the Parasite Transcriptome
S Michaeli - Future microbiology, 2011 - Taylor & Francis
In trypanosomes, all RNAs are processed by the concerted action of trans-splicing and
polyadenylation. In trans-splicing, a common spliced leader (SL) is donated to all mRNAs …
polyadenylation. In trans-splicing, a common spliced leader (SL) is donated to all mRNAs …
Implications of chimaeric non-co-linear transcripts
TR Gingeras - Nature, 2009 - nature.com
Deep sequencing of'transcriptomes'—the collection of all RNA transcripts produced at a
given time—from worms to humans reveals that some transcripts are composed of sequence …
given time—from worms to humans reveals that some transcripts are composed of sequence …
A Systematically Improved High Quality Genome and Transcriptome of the Human Blood Fluke Schistosoma mansoni
Schistosomiasis is one of the most prevalent parasitic diseases, affecting millions of people
in develo** countries. Amongst the human-infective species, Schistosoma mansoni is also …
in develo** countries. Amongst the human-infective species, Schistosoma mansoni is also …
Spliced leader RNA trans-splicing in dinoflagellates
Through the analysis of hundreds of full-length cDNAs from fifteen species representing all
major orders of dinoflagellates, we demonstrate that nuclear-encoded mRNAs in all species …
major orders of dinoflagellates, we demonstrate that nuclear-encoded mRNAs in all species …
Spliced Leader Trap** Reveals Widespread Alternative Splicing Patterns in the Highly Dynamic Transcriptome of Trypanosoma brucei
Trans-splicing of leader sequences onto the 5′ ends of mRNAs is a widespread
phenomenon in protozoa, nematodes and some chordates. Using parallel sequencing we …
phenomenon in protozoa, nematodes and some chordates. Using parallel sequencing we …
trans and cis Splicing in Trypanosomatids: Mechanism, Factors, and Regulation
X Liang, A Haritan, S Uliel, S Michaeli - Eukaryotic cell, 2003 - Am Soc Microbiol
Faculty of Life Sciences, Bar-Ilan University, Ramat-Gan, 52900 Israel mRNA maturation in
trypanosomes differs from the process in most eukaryotes mainly because protein-coding …
trypanosomes differs from the process in most eukaryotes mainly because protein-coding …
Spliceosome-mediated RNA trans-splicing as a tool for gene therapy
M Puttaraju, SF Jamison, SG Mansfield… - Nature …, 1999 - nature.com
We have developed RNA molecules capable of effecting spliceosome-mediated RNA trans-
splicing reactions with a target messenger RNA precursor (pre-mRNA). Targeted trans …
splicing reactions with a target messenger RNA precursor (pre-mRNA). Targeted trans …
A new twist in trypanosome RNA metabolism: cis-splicing of pre-mRNA
It has been known for almost a decade and a half that in trypanosomes all mRNAs are trans-
spliced by addition to the 5′ end of the spliced leader (SL) sequence. During the same time …
spliced by addition to the 5′ end of the spliced leader (SL) sequence. During the same time …
SL trans-splicing: easy come or easy go?
KEM Hastings - Trends in genetics, 2005 - cell.com
Is spliced-leader (SL) trans-splicing an ancestral eukaryotic characteristic that has been lost
in multiple lineages, or did it arise independently in the various phyla in which it occurs …
in multiple lineages, or did it arise independently in the various phyla in which it occurs …
Trans‐splicing
EL Lasda, T Blumenthal - Wiley Interdisciplinary Reviews: RNA, 2011 - Wiley Online Library
Trans‐splicing is the joining together of portions of two separate pre‐mRNA molecules. The
two distinct categories of spliceosomal trans‐splicing are genic trans‐splicing, which joins …
two distinct categories of spliceosomal trans‐splicing are genic trans‐splicing, which joins …