Although most patients with chronic pain are women, the preclinical literature regarding pain
processing and the pathophysiology of chronic pain has historically been derived …

What is known and objective Optimal utilization of opioid analgesics is significantly limited
by the central nervous system adverse effects and misuse/abuse potential of currently …

The objectives of this study were to explore the existence of subgroups in a cohort with
chronic low back pain (n 5 294) based on the results of multimodal sensory testing and …

Background Identifying risk factors and early intervention are critical for improving the
satisfaction rate of total knee arthroplasty (TKA). Our study aimed to identify patient-specific …

Background Postoperative pain poses a significant challenge to the healthcare system and
patient satisfaction and is associated with chronic pain and long-term narcotic use. However …

Neuropathic pain is defined as pain arising as a direct consequence of a lesion or a disease
affecting the somatosensory system and it affects around 1 in 4 diabetic patients in the UK …

This paper is the thirty-sixth consecutive installment of the annual review of research
concerning the endogenous opioid system. It summarizes papers published during 2013 …

Effective perioperative pain management is essential for optimal patient recovery after
surgery and reduces the risk of chronification. However, in clinical practice, perioperative …

This study investigated the association between menstrual pain severity and psychophysical
measures of cold and pressure pain sensitivity. A cross-sectional design was used with …

Genetic polymorphisms have been shown to affect opioid requirement for pain relief.
However, true genetic effect is often difficult to assess due to underlying pain conditions and …