High-throughput DNA synthesis for data storage

M Yu, X Tang, Z Li, W Wang, S Wang, M Li… - Chemical Society …, 2024 - pubs.rsc.org
With the explosion of digital world, the dramatically increasing data volume is expected to
reach 175 ZB (1 ZB= 1012 GB) in 2025. Storing such huge global data would consume tons …

DNA as a universal chemical substrate for computing and data storage

S Yang, BWA Bögels, F Wang, C Xu, H Dou… - Nature Reviews …, 2024 - nature.com
DNA computing and DNA data storage are emerging fields that are unlocking new
possibilities in information technology and diagnostics. These approaches use DNA …

Symbolic recording of signalling and cis-regulatory element activity to DNA

W Chen, J Choi, X Li, JF Nathans, B Martin, W Yang… - Nature, 2024 - nature.com
Measurements of gene expression or signal transduction activity are conventionally
performed using methods that require either the destruction or live imaging of a biological …

Engineering wired life: synthetic biology for electroactive bacteria

LJ Bird, BB Kundu, T Tschirhart, AD Corts… - ACS Synthetic …, 2021 - ACS Publications
Electroactive bacteria produce or consume electrical current by moving electrons to and
from extracellular acceptors and donors. This specialized process, known as extracellular …

A designer synthetic chromosome fragment functions in moss

LG Chen, T Lan, S Zhang, M Zhao, G Luo, Y Gao… - Nature Plants, 2024 - nature.com
Rapid advances in DNA synthesis techniques have enabled the assembly and engineering
of viral and microbial genomes, presenting new opportunities for synthetic genomics in …

Information-theoretic foundations of DNA data storage

I Shomorony, R Heckel - Foundations and Trends® in …, 2022 - nowpublishers.com
Due to its longevity and enormous information density, DNA is an attractive medium for
archival data storage. Natural DNA more than 700.000 years old has been recovered, and …

Transcriptional recording by CRISPR spacer acquisition from RNA

F Schmidt, MY Cherepkova, RJ Platt - Nature, 2018 - nature.com
The ability to record transcriptional events within a cell over time would help to elucidate
how molecular events give rise to complex cellular behaviours and states. However, current …

Programming mammalian cell behaviors by physical cues

J Huang, M Fussenegger - Trends in Biotechnology, 2024 - cell.com
In recent decades, the field of synthetic biology has witnessed remarkable progress, driving
advances in both research and practical applications. One pivotal area of development …

Recording gene expression order in DNA by CRISPR addition of retron barcodes

S Bhattarai-Kline, SK Lear, CB Fishman, SC Lopez… - Nature, 2022 - nature.com
Biological processes depend on the differential expression of genes over time, but methods
to make physical recordings of these processes are limited. Here we report a molecular …

A DNA circuit that records molecular events

M Zhang, C Yancey, C Zhang, J Wang, Q Ma… - Science …, 2024 - science.org
Characterizing the relative onset time, strength, and duration of molecular signals is critical
for understanding the operation of signal transduction and genetic regulatory networks …