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[HTML][HTML] Drug Selection and Posology, Optimal Therapies and Risk/Benefit Assessment in Medicine: The Paradigm of Iron-Chelating Drugs
The design of clinical protocols and the selection of drugs with appropriate posology are
critical parameters for therapeutic outcomes. Optimal therapeutic protocols could ideally be …
critical parameters for therapeutic outcomes. Optimal therapeutic protocols could ideally be …
Functional genomics and insights into the pathogenesis and treatment of psoriasis
Psoriasis is a lifelong, systemic, immune mediated inflammatory skin condition, affecting 1–
3% of the world's population, with an impact on quality of life similar to diseases like cancer …
3% of the world's population, with an impact on quality of life similar to diseases like cancer …
PDE4 Gene Family Variants Are Associated with Response to Apremilast Treatment in Psoriasis
Moderate-to-severe psoriasis (Ps) treatment includes systemic drugs and biological agents.
Apremilast, a small molecule primarily metabolized by cytochrome CYP3A4, modulates the …
Apremilast, a small molecule primarily metabolized by cytochrome CYP3A4, modulates the …
Paradoxical Psoriasis in Patients Receiving Therapy with Tumor Necrosis Factor Inhibitors: Potential Pathogenic Mechanisms and the Role of Genetic Factors
TNF inhibitors (TNFi) have revolutionized the therapeutic management of various chronic
immune-mediated inflammatory diseases. Despite their known benefits, these therapies are …
immune-mediated inflammatory diseases. Despite their known benefits, these therapies are …
Pharmacogenetic biomarkers for secukinumab response in psoriasis patients in real‐life clinical practice
E Muñoz‐Aceituno, B Butrón‐Bris… - Journal of the …, 2024 - Wiley Online Library
Background Prediction of the response to a biological treatment in psoriasis patients would
allow efficient treatment allocation. Objective To identify polymorphisms associated with …
allow efficient treatment allocation. Objective To identify polymorphisms associated with …
Integrating omics data for personalized medicine in treating psoriasis
Psoriasis is a chronic, multifactorial skin disorder characterized by the hyperproliferation of
keratinocytes and persistent inflammation. It is driven by a complex interplay of genetic …
keratinocytes and persistent inflammation. It is driven by a complex interplay of genetic …
Treatment of Chronic Plaque Psoriasis: An Overview on Current Update
Introduction Chronic plaque psoriasis is an inflammatory skin disorder that affects 2% to 3%
of the population. The severity of the disease is influenced by the number and location of …
of the population. The severity of the disease is influenced by the number and location of …
Polymorphisms of PDCD1 and COL9A1 Genes in Plaque, Palmoplantar and Arthropathic Psoriasis in Romanian Patients
In recent years, genetic studies have brought new insights into psoriasis, a chronic
inflammatory disease with multiple determining and favoring factors. Recent advances in the …
inflammatory disease with multiple determining and favoring factors. Recent advances in the …
[HTML][HTML] The new era of immune skin diseases: Exploring advances in basic research and clinical translations
B Zhang, X Mei, M Zhao, Q Lu - Journal of Translational Autoimmunity, 2024 - Elsevier
As a vital immune organ, skin performs multiple physiological functions. Immune skin
diseases (ISDs) arecharacterized by dysregulated immune responses, manifested as …
diseases (ISDs) arecharacterized by dysregulated immune responses, manifested as …
Psoriasis-Interactions Between Genetic Susceptibility, Bacterial Microbiome, and Gene Expression
M Assarsson - 2024 - diva-portal.org
Psoriasis is a common immune-mediated inflammatory disease, caused by a combination of
genetic predisposition and environmental trigger factors. In spite of extensive research …
genetic predisposition and environmental trigger factors. In spite of extensive research …