In situ label-free X-ray imaging for visualizing the localization of nanomedicines and subcellular architecture in intact single cells

M Cao, Y Wang, L Wang, K Zhang, Y Guan, Y Guo… - Nature …, 2024 - nature.com
Understanding the intracellular behaviors of nanomedicines and morphology variation of
subcellular architecture impacted by nanomaterial–biology (nano–bio) interactions could …

Nitrogen-fixing organelle in a marine alga

TH Coale, V Loconte, KA Turk-Kubo, B Vanslembrouck… - Science, 2024 - science.org
Symbiotic interactions were key to the evolution of chloroplast and mitochondria organelles,
which mediate carbon and energy metabolism in eukaryotes. Biological nitrogen fixation, the …

Soft X‐ray tomograms provide a structural basis for whole‐cell modeling

V Loconte, JH Chen, B Vanslembrouck… - The FASEB …, 2023 - Wiley Online Library
Develo** in silico models that accurately reflect a whole, functional cell is an ongoing
challenge in biology. Current efforts bring together mathematical models, probabilistic …

Using soft X-ray tomography for rapid whole-cell quantitative imaging of SARS-CoV-2-infected cells

V Loconte, JH Chen, M Cortese, A Ekman… - Cell reports …, 2021 - cell.com
High-resolution and rapid imaging of host cell ultrastructure can generate insights toward
viral disease mechanism, for example for a severe acute respiratory syndrome coronavirus …

Soft X-ray tomography to map and quantify organelle interactions at the mesoscale

V Loconte, J Singla, A Li, JH Chen, A Ekman… - Structure, 2022 - cell.com
Inter-organelle interactions are a vital part of normal cellular function; however, these have
proven difficult to quantify due to the range of scales encountered in cell biology and the …

Three-dimensional label-free observing of the self-assembled nanoparticles inside a single cell at nanoscale resolution

H Zhou, Y Guo, T Fu, Y Peng, Z Chen, Y Cui, M Guo… - ACS …, 2024 - ACS Publications
Understanding the intracellular behavior of nanoparticles (NPs) plays a key role in
optimizing the self-assembly performance of nanomedicine. However, conducting the 3D …

Bayesian metamodeling of complex biological systems across varying representations

B Raveh, L Sun, KL White, T Sanyal, J Tempkin… - Proceedings of the …, 2021 - pnas.org
Comprehensive modeling of a whole cell requires an integration of vast amounts of
information on various aspects of the cell and its parts. To divide and conquer this task, we …

Insulator-based dielectrophoresis-assisted separation of insulin secretory vesicles

M Barekatain, Y Liu, A Archambeau, V Cherezov… - Elife, 2024 - elifesciences.org
Organelle heterogeneity and inter-organelle contacts within a single cell contribute to the
limited sensitivity of current organelle separation techniques, thus hindering organelle …

Reagents and models for detecting endogenous GLP1R and GIPR

J Ast, J Broichhagen, DJ Hodson - EBioMedicine, 2021 - thelancet.com
Abstract Glucagon-like peptide-1 receptor (GLP1R) agonists target the GLP1R, whereas
dual GLP1R/gastric inhibitory polypeptide receptor (GIPR) agonists target both the GLP1R …

Advanced light source analytical techniques for exploring the biological behavior and fate of nanomedicines

M Cao, K Zhang, S Zhang, Y Wang… - ACS Central Science, 2022 - ACS Publications
Exploration of the biological behavior and fate of nanoparticles, as affected by the
nanomaterial–biology (nano–bio) interaction, has become progressively critical for guiding …